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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Common variants associated with general and MMR vaccine–related febrile seizures
|
|---|---|
| Published in |
Nature Genetics, October 2014
|
| DOI | 10.1038/ng.3129 |
| Pubmed ID | |
| Authors |
Bjarke Feenstra, Björn Pasternak, Frank Geller, Lisbeth Carstensen, Tongfei Wang, Fen Huang, Jennifer L Eitson, Mads V Hollegaard, Henrik Svanström, Mogens Vestergaard, David M Hougaard, John W Schoggins, Lily Yeh Jan, Mads Melbye, Anders Hviid |
| Abstract |
Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination. We conducted a series of genome-wide association scans comparing children with MMR-related febrile seizures, children with febrile seizures unrelated to vaccination and controls with no history of febrile seizures. Two loci were distinctly associated with MMR-related febrile seizures, harboring the interferon-stimulated gene IFI44L (rs273259: P = 5.9 × 10(-12) versus controls, P = 1.2 × 10(-9) versus MMR-unrelated febrile seizures) and the measles virus receptor CD46 (rs1318653: P = 9.6 × 10(-11) versus controls, P = 1.6 × 10(-9) versus MMR-unrelated febrile seizures). Furthermore, four loci were associated with febrile seizures in general, implicating the sodium channel genes SCN1A (rs6432860: P = 2.2 × 10(-16)) and SCN2A (rs3769955: P = 3.1 × 10(-10)), a TMEM16 family gene (ANO3; rs114444506: P = 3.7 × 10(-20)) and a region associated with magnesium levels (12q21.33; rs11105468: P = 3.4 × 10(-11)). Finally, we show the functional relevance of ANO3 (TMEM16C) with electrophysiological experiments in wild-type and knockout rats. |
X Demographics
The data shown below were collected from the profiles of 87 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 32% |
| Denmark | 3 | 3% |
| Australia | 3 | 3% |
| United Kingdom | 3 | 3% |
| Japan | 2 | 2% |
| Spain | 2 | 2% |
| Hungary | 1 | 1% |
| Iceland | 1 | 1% |
| Sweden | 1 | 1% |
| Other | 6 | 7% |
| Unknown | 37 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 62 | 71% |
| Scientists | 20 | 23% |
| Practitioners (doctors, other healthcare professionals) | 3 | 3% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 161 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 22% |
| Student > Ph. D. Student | 23 | 14% |
| Student > Bachelor | 21 | 13% |
| Student > Master | 20 | 12% |
| Other | 13 | 8% |
| Other | 30 | 18% |
| Unknown | 24 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 28% |
| Agricultural and Biological Sciences | 32 | 19% |
| Biochemistry, Genetics and Molecular Biology | 19 | 11% |
| Neuroscience | 15 | 9% |
| Immunology and Microbiology | 7 | 4% |
| Other | 13 | 8% |
| Unknown | 35 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 121. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2024.
All research outputs
#352,032
of 25,768,270 outputs
Outputs from Nature Genetics
#666
of 7,621 outputs
Outputs of similar age
#3,458
of 274,712 outputs
Outputs of similar age from Nature Genetics
#5
of 70 outputs
Altmetric has tracked 25,768,270 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,621 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,712 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.