Title |
Neutrophil extracellular traps in patients with pulmonary tuberculosis
|
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Published in |
Respiratory Research, October 2017
|
DOI | 10.1186/s12931-017-0663-1 |
Pubmed ID | |
Authors |
Anne Jan van der Meer, Sacha Zeerleder, Dana C. Blok, Liesbeth M. Kager, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Md Abu Tayab, Arjen M. Dondorp, Tom van der Poll |
Abstract |
Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs release in the circulation during human tuberculosis. For this we measured the plasma concentrations of nucleosomes in conjunction with neutrophil elastase, in 64 patients with active pulmonary tuberculosis and 32 healthy controls. Patients with active tuberculosis had elevated plasma levels of nucleosomes and elastase when compared with local healthy blood donors. Furthermore nucleosome and elastase levels showed a positive correlation. These findings provide the first evidence for the release of NETs in the circulation of patients with active pulmonary tuberculosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 43% |
India | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 18% |
Student > Ph. D. Student | 8 | 14% |
Other | 7 | 13% |
Student > Master | 7 | 13% |
Student > Bachelor | 6 | 11% |
Other | 5 | 9% |
Unknown | 13 | 23% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Medicine and Dentistry | 9 | 16% |
Agricultural and Biological Sciences | 6 | 11% |
Unspecified | 2 | 4% |
Other | 4 | 7% |
Unknown | 14 | 25% |