Title |
O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males
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Published in |
Diabetology & Metabolic Syndrome, September 2014
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DOI | 10.1186/1758-5996-6-96 |
Pubmed ID | |
Authors |
Jason P Myslicki, Jane Shearer, Dustin S Hittel, Curtis C Hughey, Darrell D Belke |
Abstract |
Hemoglobin A1c (HbA1c) is the predominant diagnostic tool for diabetes diagnosis and progression. However, it has proven to be insensitive at pre-diabetic threshold values. O-linked-β-N-acetylglucosamine (O-GlcNAc) modification has emerged as a sensitive biomarker. The purpose of this study was to explore the sensitivity of O-GlcNAc expression as a potential marker of early metabolic dysfunction in a young adult population. Healthy, young males (18-35 y) from the Assessing Inherited Metabolic syndrome Markers in the Young study (AIMMY), were divided into low (LH,0.60) or high (HH,1.61) homeostatic model assessment of insulin resistance (HOMA-IR) cohorts. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Ireland | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 18% |
Student > Master | 6 | 15% |
Student > Ph. D. Student | 5 | 13% |
Other | 4 | 10% |
Student > Bachelor | 2 | 5% |
Other | 6 | 15% |
Unknown | 10 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 28% |
Chemistry | 4 | 10% |
Medicine and Dentistry | 4 | 10% |
Nursing and Health Professions | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Other | 4 | 10% |
Unknown | 11 | 28% |