@philosophising4 @mkaeberlein Interesting: «People with DS display higher levels of many pro-inflammatory cytokines (e.g. IL-6, MCP-1, IL-22, TNF-α) and pronounced complement consumption, resembling changes seen in type I interferonopathies and other autoi
Incredible fascinating research that explains so much about the complications to T21—Immune response therapies may be grounds for improved management of the many conditions that may arise over the life course of a person with #Downsyndrome! https://t.co/d0
@axoxnxs @GDSFoundation @NDSS @JLFoundation We have shown that trisomy 21 activates the interferon response in people with Down syndrome, causing widespread immune dysregulation. This could explain the increase in autoimmune disorders in DS. https://t.co/
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation https://t.co/Xz3iRRpn7o