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Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney

Overview of attention for article published in American Journal of Physiology: Renal Physiology, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

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4 tweeters
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2 Facebook pages

Citations

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13 Dimensions

Readers on

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24 Mendeley
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Title
Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney
Published in
American Journal of Physiology: Renal Physiology, December 2014
DOI 10.1152/ajprenal.00024.2014
Pubmed ID
Authors

Michelle M. Duffy, Bairbre A. McNicholas, David A. Monaghan, Shirley A. Hanley, Jill M. McMahon, Jana Pindjakova, Senthilkumar Alagesan, Howard O. Fearnhead, Matthew D. Griffin

Abstract

Mesenchymal stem cells (MSCs) suppress T-helper (Th)-17 cell differentiation and are being pursued clinically for the treatment of conditions associated with aberrant Th17 responses. Whether such immunomodulatory effects are enhanced by co-administration of MSCs with other agents is not well known. In this study, the individual and combined effects of MSCs and the vitamin D receptor (VDR) agonist paricalcitol on Th17 induction were investigated in vitro and in a mouse model of sterile kidney inflammation (unilateral ureteral obstruction). In-vitro, MSCs and paricalcitol additively suppressed Th17 differentiation although only MSCs suppressed expression of Th17-associated transcriptions factors. The combined administration of MSCs and paricalcitol resulted in early (day 3) reduction of intra-renal CD4(+) and CD8(+) T-cells, CD11b(+)/Ly6G(+) neutrophils and inflammatory (Ly6C(hi)) monocytes as well as reduced transcript for IL-17. Later (day 8), obstructed kidneys of MSC and paricalcitol double-treated, but not single-treated, mice had reduced tubular injury and interstitial fibrosis as well as lower numbers of neutrophils and inflammatory monocytes and an increase in the ratio between M2 (CD206(+)) and M1 (CD206(-)) macrophages compared to controls. Adjunctive therapy with VDR agonists may represent a strategy for enhancing the immunosuppressive properties of MSCs in the setting of pathogenic Th17-type immune responses and related inflammatory responses.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 25%
Student > Master 6 25%
Other 3 13%
Student > Ph. D. Student 2 8%
Student > Bachelor 2 8%
Other 6 25%
Readers by discipline Count As %
Medicine and Dentistry 8 33%
Agricultural and Biological Sciences 7 29%
Immunology and Microbiology 2 8%
Nursing and Health Professions 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 3 13%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2015.
All research outputs
#7,069,128
of 13,485,799 outputs
Outputs from American Journal of Physiology: Renal Physiology
#660
of 1,835 outputs
Outputs of similar age
#84,644
of 232,516 outputs
Outputs of similar age from American Journal of Physiology: Renal Physiology
#11
of 53 outputs
Altmetric has tracked 13,485,799 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,835 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,516 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.