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Mendeley readers
Attention Score in Context
| Title |
Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation
|
|---|---|
| Published in |
Journal of Translational Medicine, November 2014
|
| DOI | 10.1186/s12967-014-0302-2 |
| Pubmed ID | |
| Authors |
Haiwen Yu, Min Tang, Jun Yu, Xiaohong Zhou, Lepeng Zeng, Shu Zhang |
| Abstract |
BackgroundAutonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could prevent left ventricular (LV) remodeling and dysfunction in a canine HF model induced by chronic mitral regurgitation (MR).Methods and resultsAfter the MR inducing procedure, 12 survived canines were randomly divided into the control (n¿=¿6) and the VNS (n¿=¿6) groups. At month 2, a VNS stimulator system was implanted in all canines. From month 3 to month 6, VNS therapy was applied in the VNS group but not in the control group. At month 6, compared with the control group, the canines in VNS group had significantly higher cardiac output (2.3¿±¿0.3 versus 2.9¿±¿0.4 L/min, P¿<¿0.05 , LV forward stroke volume (20.1¿±¿3.7 versus 24.8¿±¿3.9 ml, P¿<¿0.05), and end-systolic stiffness constant (2.2¿±¿0.3 versus 2.7¿±¿0.3, P¿<¿0.05). NT-proBNP and C-reactive protein were decreased significantly in the VNS group. However, no statistical difference was found in LV ejection fraction, LV end-diastolic dimension, LV end-diastolic volume, myocyte cross-sectional area, or collagen volume fraction between two groups.ConclusionsChronic VNS therapy may ameliorate MR-induced LV contractile dysfunction and improve the expression of biomarkers, but has less effect in improving LV chamber remodeling. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 18% |
| Student > Ph. D. Student | 5 | 18% |
| Researcher | 4 | 14% |
| Student > Postgraduate | 2 | 7% |
| Student > Master | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 10 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 21% |
| Neuroscience | 4 | 14% |
| Engineering | 2 | 7% |
| Agricultural and Biological Sciences | 2 | 7% |
| Psychology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 12 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2014.
All research outputs
#20,242,136
of 22,769,322 outputs
Outputs from Journal of Translational Medicine
#3,305
of 3,982 outputs
Outputs of similar age
#218,767
of 262,191 outputs
Outputs of similar age from Journal of Translational Medicine
#72
of 97 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,982 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.