Title |
Genetic therapies for cystic fibrosis lung disease
|
---|---|
Published in |
Current Opinion in Pharmacology, November 2017
|
DOI | 10.1016/j.coph.2017.10.006 |
Pubmed ID | |
Authors |
Stephen L Hart, Patrick T Harrison |
Abstract |
Gene therapy for cystic fibrosis (CF) has been the subject of intense research over the last twenty-five years or more, using both viral and liposomal delivery methods, but so far without the emergence of a clinical therapy. New approaches to CF gene therapy involving recent improvements to vector systems, both viral and non-viral, as well as new nucleic acid technologies have led to renewed interest in the field. The field of therapeutic gene editing is rapidly developing with the emergence of CRISPR/Cas9 as well as chemically modified mRNA therapeutics. These new types of nucleic acid therapies are also a good fit with delivery by non-viral delivery approaches which has led to a renewed interest in lipid-based and other nanoformulations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 138 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 48 | 35% |
Student > Ph. D. Student | 14 | 10% |
Student > Master | 13 | 9% |
Researcher | 8 | 6% |
Student > Doctoral Student | 5 | 4% |
Other | 7 | 5% |
Unknown | 43 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 25% |
Medicine and Dentistry | 16 | 12% |
Agricultural and Biological Sciences | 13 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
Nursing and Health Professions | 8 | 6% |
Other | 11 | 8% |
Unknown | 45 | 33% |