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Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

Overview of attention for article published in Journal of Neuroinflammation, November 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

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5 tweeters
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3 Facebook pages
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1 Google+ user

Citations

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21 Dimensions

Readers on

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76 Mendeley
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Title
Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia
Published in
Journal of Neuroinflammation, November 2014
DOI 10.1186/s12974-014-0183-6
Pubmed ID
Authors

Jacquelyn A Brown, Stacy D Sherrod, Cody R Goodwin, Bryson Brewer, Lijie Yang, Krassimira A Garbett, Deyu Li, John A McLean, John P Wikswo, Károly Mirnics

Abstract

BackgroundMaternal immune activation and subsequent interleukin-6 (IL-6) induction disrupt normal brain development and predispose the offspring to developing autism and schizophrenia. While several proteins have been identified as having some link to these developmental disorders, their prevalence is still small and their causative role, if any, is not well understood. However, understanding the metabolic consequences of environmental predisposing factors could shed light onto disorders such as autism and schizophrenia.MethodsTo gain a better understanding of the metabolic consequences of IL-6 exposure on developing central nervous system (CNS) cells, we separately exposed developing neuron and astroglia cultures to IL-6 for 2 hours while collecting effluent from our gravity-fed microfluidic chambers. By coupling microfluidic technologies to ultra-performance liquid chromatography-ion mobility-mass spectrometry (UPLC-IM-MS), we were able to characterize the metabolic response of these CNS cells to a narrow window of IL-6 exposure.ResultsOur results revealed that 1) the use of this technology, due to its superb media volume:cell volume ratio, is ideally suited for analysis of cell-type-specific exometabolome signatures; 2) developing neurons have low secretory activity at baseline, while astroglia show strong metabolic activity; 3) both neurons and astroglia respond to IL-6 exposure in a cell type-specific fashion; 4) the astroglial response to IL-6 stimulation is predominantly characterized by increased levels of metabolites, while neurons mostly depress their metabolic activity; and 5) disturbances in glycerophospholipid metabolism and tryptophan/kynurenine metabolite secretion are two putative mechanisms by which IL-6 affects the developing nervous system.ConclusionsOur findings are potentially critical for understanding the mechanism by which IL-6 disrupts brain function, and they provide information about the molecular cascade that links maternal immune activation to developmental brain disorders.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Poland 1 1%
Brazil 1 1%
Unknown 73 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 29%
Student > Bachelor 9 12%
Researcher 9 12%
Student > Master 7 9%
Other 7 9%
Other 15 20%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 18%
Medicine and Dentistry 13 17%
Neuroscience 9 12%
Biochemistry, Genetics and Molecular Biology 6 8%
Psychology 6 8%
Other 15 20%
Unknown 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2014.
All research outputs
#3,964,947
of 14,061,530 outputs
Outputs from Journal of Neuroinflammation
#514
of 1,673 outputs
Outputs of similar age
#62,604
of 234,499 outputs
Outputs of similar age from Journal of Neuroinflammation
#14
of 53 outputs
Altmetric has tracked 14,061,530 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,673 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.