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Immune-related adverse events of immune checkpoint inhibitors

Overview of attention for article published in Japanese Journal of Clinical Immunology, January 2017
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1 tweeter

Citations

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5 Dimensions

Readers on

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27 Mendeley
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Title
Immune-related adverse events of immune checkpoint inhibitors
Published in
Japanese Journal of Clinical Immunology, January 2017
DOI 10.2177/jsci.40.102
Pubmed ID
Authors

Hiroki TADANO, Toshihiko TORIGOE

Abstract

  Development and application of anti-CTLA-4 antibody and anti-PD-1 antibody to cancer immunotherapy brought great survival benefits to advanced cancer patients. They have been applied to various cancers such as melanoma, non-small cell lung cancer, renal cell cancer, Hodgkin's disease, and head and neck cancers, and there is no doubt that immunotherapy is becoming a standard therapy as well as surgery, chemotherapy, and radiotherapy. On the other hand, immune-related adverse events (irAEs) have been increasingly reported. Nevertheless, mechanisms of the immune-mediated toxicities are still unclear. There has been a growing interest in the elucidation of the mechanisms. This review describes the general characteristics of irAEs induced by immune checkpoint inhibitors, especially 1. Heterogeneity, 2. Multiplicity, 3. Durability, and 4. Correlativity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 19%
Student > Bachelor 4 15%
Student > Master 4 15%
Student > Postgraduate 3 11%
Student > Ph. D. Student 1 4%
Other 2 7%
Unknown 8 30%
Readers by discipline Count As %
Medicine and Dentistry 11 41%
Biochemistry, Genetics and Molecular Biology 3 11%
Psychology 1 4%
Nursing and Health Professions 1 4%
Earth and Planetary Sciences 1 4%
Other 1 4%
Unknown 9 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2017.
All research outputs
#7,573,943
of 12,119,647 outputs
Outputs from Japanese Journal of Clinical Immunology
#88
of 145 outputs
Outputs of similar age
#160,610
of 285,054 outputs
Outputs of similar age from Japanese Journal of Clinical Immunology
#3
of 5 outputs
Altmetric has tracked 12,119,647 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 145 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,054 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.