Title |
免疫チェックポイント阻害剤の免疫性副作用
|
---|---|
Published in |
Immunological Medicine, January 2017
|
DOI | 10.2177/jsci.40.102 |
Pubmed ID | |
Authors |
Hiroki Tadano, Toshihiko Torigoe |
Abstract |
Development and application of anti-CTLA-4 antibody and anti-PD-1 antibody to cancer immunotherapy brought great survival benefits to advanced cancer patients. They have been applied to various cancers such as melanoma, non-small cell lung cancer, renal cell cancer, Hodgkin's disease, and head and neck cancers, and there is no doubt that immunotherapy is becoming a standard therapy as well as surgery, chemotherapy, and radiotherapy. On the other hand, immune-related adverse events (irAEs) have been increasingly reported. Nevertheless, mechanisms of the immune-mediated toxicities are still unclear. There has been a growing interest in the elucidation of the mechanisms. This review describes the general characteristics of irAEs induced by immune checkpoint inhibitors, especially 1. Heterogeneity, 2. Multiplicity, 3. Durability, and 4. Correlativity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 7 | 20% |
Student > Master | 5 | 14% |
Researcher | 5 | 14% |
Student > Bachelor | 5 | 14% |
Student > Postgraduate | 3 | 9% |
Other | 3 | 9% |
Unknown | 7 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 8 | 23% |
Medicine and Dentistry | 7 | 20% |
Biochemistry, Genetics and Molecular Biology | 6 | 17% |
Agricultural and Biological Sciences | 2 | 6% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 23% |