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Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

Overview of attention for article published in Nature, December 1994
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2 patents

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Title
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
Published in
Nature, December 1994
DOI 10.1038/372563a0
Pubmed ID
Authors

Jörg Großhans, Andreas Bergmann, Pascal Haffter, Christiane Nüsslein-Volhard

Abstract

The concentration of Dorsal protein in the nucleus determines cell fate along the dorsoventral axis of the Drosophila embryo. The dorsal-group genes and the cactus gene are required for production and transmission of a localized signal on the ventral side of the embryo which determines the position of the highest nuclear concentration of Dorsal protein. The ventralizing signal produced in somatic cells is transmitted through the perivitelline space to the integral membrane protein Toll. Inside the embryo it leads to dissociation of the cytoplasmic Dorsal-Cactus complex and subsequent nuclear localization of Dorsal protein. Two components are known to mediate the signal transduction between Toll and Dorsal-Cactus: Pelle, a serine/threonine protein kinase, and Tube, a protein with an unknown biochemical activity. Here we construct gain-of-function alleles of pelle and tube and show that pelle functions downstream of tube. In addition, Pelle and Tube interact directly with one another. We propose that Tube is a direct activator of the protein kinase Pelle.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 7%
France 1 2%
Unknown 37 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Researcher 5 12%
Student > Doctoral Student 4 10%
Professor > Associate Professor 4 10%
Professor 4 10%
Other 8 20%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 44%
Biochemistry, Genetics and Molecular Biology 7 17%
Computer Science 2 5%
Engineering 2 5%
Immunology and Microbiology 2 5%
Other 3 7%
Unknown 7 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2003.
All research outputs
#7,541,526
of 23,007,887 outputs
Outputs from Nature
#65,669
of 91,334 outputs
Outputs of similar age
#16,063
of 76,359 outputs
Outputs of similar age from Nature
#108
of 179 outputs
Altmetric has tracked 23,007,887 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 91,334 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.6. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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