Cost‐effectiveness of personal tailored risk information and taster sessions to increase the uptake of the NHS stop smoking services: the Start2quit randomized controlled trial

Qi Wu, Hazel Gilbert, Irwin Nazareth, Stephen Sutton, Richard Morris, Irene Petersen, Simon Galton, Steve Parrott

To assess the cost-effectiveness of a two-component intervention designed to increase attendance at the NHS Stop Smoking Services (SSSs) in England. Cost-effectiveness analysis alongside a randomised controlled trial (Start2quit). NHS SSS and general practices in England. The study comprised 4,384 smokers aged 16 or over identified from medical records in 99 participating practices, who were motivated to quit and had not attended the SSS in the previous 12 months. Intervention was a personalised and tailored letter sent from the General Practitioner (GP), and a personal invitation and appointment to attend a taster session providing information about SSS. Control was a standard generic letter from the GP advertising SSS and asking smokers to contact the service to make an appointment. Costs measured from an NHS/Personal Social Services perspective. Estimated health gains in quality-adjusted life-years (QALYs) measured with EQ-5D. Incremental cost per QALY gained over six-month and over a lifetime horizon. During the trial period, the adjusted mean difference in costs was £92 (95% CI: -£32-£216) and the adjusted mean difference in QALY gains was 0.002 (95% CI: -0.001-0.004). This generates an incremental cost per QALY gained of £59,401. The probability that the tailored letter and taster session is more cost-effective than the generic letter at six-month is never above 50%. In contrast, the discounted lifetime health care cost was lower in the intervention group while the lifetime QALY gains were significantly higher. The probability that the intervention is more cost-effective is over 83% using a £20,000-£30,000 per QALY gained decision-making threshold. An intervention designed to increase attendance at the NHS Stop Smoking Services (tailored letter and taster session in the services) appears less likely to be cost-effective than a generic letter in the short-term but is likely to become more cost-effective than the generic letter in the long term.