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Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer

Overview of attention for article published in Journal of Translational Medicine, November 2014
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Mentioned by

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2 tweeters

Citations

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28 Dimensions

Readers on

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35 Mendeley
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Title
Enhanced frequency and potential mechanism of B regulatory cells in patients with lung cancer
Published in
Journal of Translational Medicine, November 2014
DOI 10.1186/s12967-014-0304-0
Pubmed ID
Authors

Jiebai Zhou, Zhihui Min, Ding Zhang, William Wang, Francesco Marincola, Xiangdong Wang

Abstract

BackgroundRegulatory T cells (Tregs) and B cells (Bregs) play an important role in the development of lung cancer. The present study aimed to investigate the phenotype of circulating Tregs and Bregs in patients with lung cancer and explore potential mechanism by which lung cancer cells act on the development of both.MethodsPatients with lung cancer (n¿=¿268) and healthy donors (n¿=¿65) were enrolled in the study. Frequencies of Tregs and Bregs were measured by flow cytometry with antibodies against CD4, CD25, CD127, CD45RA, CD19, CD24, CD27 and IL-10 before and after co-cultures. qRT-PCR was performed to evaluate the mRNA levels of RANTES, MIP-1¿, TGF-ß, IFN-¿ and IL-4.ResultsWe found a lower frequency of Tregs and a higher frequency of Bregs in patients with lung cancer compared to healthy donors. Co-culture of lung cancer cells with peripheral blood mononuclear cells could polarize the lymphocyte phenotype in the similar pattern. Lipopolysaccharide (LPS)-stimulated lung cancer cells significantly modulated regulatory cell number and function in an in vitro model.ConclusionWe provide initial evidence that frequencies of peripheral Tregs decreased or Bregs increased in patients with lung cancer, which may be modulated directly by lung cancer cells. It seems cancer cells per se plays a crucial role in the development of tumor immunity.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 23%
Student > Ph. D. Student 7 20%
Student > Master 7 20%
Student > Bachelor 3 9%
Student > Doctoral Student 3 9%
Other 4 11%
Unknown 3 9%
Readers by discipline Count As %
Medicine and Dentistry 8 23%
Biochemistry, Genetics and Molecular Biology 7 20%
Agricultural and Biological Sciences 5 14%
Immunology and Microbiology 3 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 9%
Unknown 8 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2016.
All research outputs
#7,507,508
of 12,450,491 outputs
Outputs from Journal of Translational Medicine
#1,300
of 2,446 outputs
Outputs of similar age
#110,259
of 231,756 outputs
Outputs of similar age from Journal of Translational Medicine
#77
of 138 outputs
Altmetric has tracked 12,450,491 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,446 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,756 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.