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Diagnostic and prognostic value of CEA, CA19–9, AFP and CA125 for early gastric cancer

Overview of attention for article published in BMC Cancer, November 2017
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1 tweeter

Citations

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78 Dimensions

Readers on

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51 Mendeley
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Title
Diagnostic and prognostic value of CEA, CA19–9, AFP and CA125 for early gastric cancer
Published in
BMC Cancer, November 2017
DOI 10.1186/s12885-017-3738-y
Pubmed ID
Authors

Fan Feng, Yangzi Tian, Guanghui Xu, Zhen Liu, Shushang Liu, Gaozan Zheng, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang

Abstract

The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19-9 (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer. From September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center. The clinicopathological characteristics were recorded. The association between levels of CEA and CA19-9 and clinicopathological characteristics and prognosis of patients were analyzed. There were 444 men (75.6%) and 143 women (24.4%). The median age was 57 years (ranged 21-85). The 1-, 3- and 5-year overall survival rate was 99.1%, 96.8% and 93.1%, respectively. The positive rate of CEA, CA19-9, AFP and CA125 was 4.3%, 4.8%, 1.5% and 1.9%, respectively. The positive rate of all markers combined was 10.4%. The associations between the clinicopathological features and levels of CEA and CA19-9 were analyzed. No significant association was found between CEA level and clinicopathological features. However, elevated CA19-9 level was correlated with female gender and presence of lymph node metastasis. Age > 60 years old, presence of lymph node metastasis and elevation of CEA level were independent risk factors for poor prognosis of early gastric cancer. The positive rates of CEA, CA19-9, APF and CA125 were relatively low for early gastric cancer. Elevation of CA19-9 level was associated with female gender and presence of lymph node metastasis. Elevation of CEA level was an independent risk factor for the poor prognosis of early gastric cancer.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 18%
Other 6 12%
Student > Bachelor 6 12%
Student > Doctoral Student 6 12%
Student > Ph. D. Student 3 6%
Other 8 16%
Unknown 13 25%
Readers by discipline Count As %
Medicine and Dentistry 16 31%
Biochemistry, Genetics and Molecular Biology 11 22%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 1 2%
Other 3 6%
Unknown 16 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2017.
All research outputs
#7,576,894
of 12,124,842 outputs
Outputs from BMC Cancer
#2,164
of 4,438 outputs
Outputs of similar age
#158,785
of 281,866 outputs
Outputs of similar age from BMC Cancer
#109
of 268 outputs
Altmetric has tracked 12,124,842 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,438 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,866 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 268 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.