Title |
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
|
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Published in |
BMC Biology, November 2014
|
DOI | 10.1186/s12915-014-0094-0 |
Pubmed ID | |
Authors |
Raymond J Deshaies |
Abstract |
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inhibitors have not proved effective in treating other cancers, and this has called into question the general applicability of this approach. Here, I consider possible explanations for this apparently limited applicability, and discuss whether inhibiting other broadly acting components of the ubiquitin-proteasome system - including ubiquitin-activating enzyme and the AAA-ATPase p97/VCP - might be more generally effective in cancer therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
India | 1 | <1% |
Russia | 1 | <1% |
Vietnam | 1 | <1% |
Unknown | 267 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 62 | 23% |
Researcher | 40 | 15% |
Student > Master | 36 | 13% |
Student > Bachelor | 30 | 11% |
Student > Doctoral Student | 14 | 5% |
Other | 43 | 16% |
Unknown | 47 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 84 | 31% |
Agricultural and Biological Sciences | 67 | 25% |
Medicine and Dentistry | 24 | 9% |
Chemistry | 17 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
Other | 16 | 6% |
Unknown | 54 | 20% |