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Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosis

Overview of attention for article published in Clinical Epigenetics, November 2014
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Title
Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosis
Published in
Clinical Epigenetics, November 2014
DOI 10.1186/1868-7083-6-25
Pubmed ID
Authors

YaoYao Wang, Ye Shu, YangFan Xiao, Qing Wang, Takuro Kanekura, YaPing Li, JiuCun Wang, Ming Zhao, QianJin Lu, Rong Xiao

Abstract

The pathogenesis and etiology of systemic sclerosis (SSc) are complex and poorly understood. To date, several studies have demonstrated that the activation of the immune system undoubtedly plays a pivotal role in SSc pathogenesis. Activated immune effector T cells contribute to the release of various pro-inflammatory cytokines and drive the SSc-specific autoantibody responses. This, and a profibrotic environment, are all-important components of abnormal active immune responses that can lead to pathological disorders of SSc. CD11a is essential to inflammatory and immune responses, regulating adhesive and co-stimulatory interactions between CD4(+) T cells and other cells. Although CD11a is overexpressed in SSc patients, the mechanisms leading to this overexpression and its consequences remain unclear. DNA methylation, a main epigenetic modification, plays an important role in the regulation of gene expression and is involved in the pathogenesis of autoimmune diseases. This work aims to investigate the effect of DNA demethylation on CD11a expression in SSc CD4(+) T cells and to determine its functional significance. CD11a expression was measured using RT-PCR and flow cytometry. Bisulfite sequencing was used to determine the methylation status of the CD11a regulatory region. CD4(+) T cells were co-cultured with antigen-presenting cells, B cells, or fibroblasts with and without anti-CD11a, and proliferation of CD4(+) T cells, IgG production by B cells, and expression levels of COL1A2 mRNA by fibroblasts were evaluated.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Student > Postgraduate 5 15%
Student > Master 5 15%
Student > Ph. D. Student 5 15%
Student > Bachelor 3 9%
Other 2 6%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 24%
Biochemistry, Genetics and Molecular Biology 7 21%
Medicine and Dentistry 7 21%
Immunology and Microbiology 3 9%
Nursing and Health Professions 1 3%
Other 0 0%
Unknown 8 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2014.
All research outputs
#13,923,205
of 22,770,070 outputs
Outputs from Clinical Epigenetics
#702
of 1,243 outputs
Outputs of similar age
#130,259
of 258,972 outputs
Outputs of similar age from Clinical Epigenetics
#8
of 14 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,972 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.