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Pharmacological potential of tocotrienols: a review

Overview of attention for article published in Nutrition & Metabolism, November 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)

Mentioned by

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5 tweeters
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3 Facebook pages

Citations

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192 Dimensions

Readers on

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369 Mendeley
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Title
Pharmacological potential of tocotrienols: a review
Published in
Nutrition & Metabolism, November 2014
DOI 10.1186/1743-7075-11-52
Pubmed ID
Authors

Haseeb Ahsan, Amjid Ahad, Jahangir Iqbal, Waseem A Siddiqui

Abstract

Tocotrienols, members of the vitamin E family, are natural compounds found in a number of vegetable oils, wheat germ, barley, and certain types of nuts and grains. Like tocopherols, tocotrienols are also of four types viz. alpha, beta, gamma and delta. Unlike tocopherols, tocotrienols are unsaturated and possess an isoprenoid side chain. Tocopherols are lipophilic in nature and are found in association with lipoproteins, fat deposits and cellular membranes and protect the polyunsaturated fatty acids from peroxidation reactions. The unsaturated chain of tocotrienol allows an efficient penetration into tissues that have saturated fatty layers such as the brain and liver. Recent mechanistic studies indicate that other forms of vitamin E, such as γ-tocopherol, δ-tocopherol, and γ-tocotrienol, have unique antioxidant and anti-inflammatory properties that are superior to those of α-tocopherol against chronic diseases. These forms scavenge reactive nitrogen species, inhibit cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids and suppress proinflammatory signalling, such as NF-κB and STAT. The animal and human studies show tocotrienols may be useful against inflammation-associated diseases. Many of the functions of tocotrienols are related to its antioxidant properties and its varied effects are due to it behaving as a signalling molecule. Tocotrienols exhibit biological activities that are also exhibited by tocopherols, such as neuroprotective, anti-cancer, anti-inflammatory and cholesterol lowering properties. Hence, effort has been made to compile the different functions and properties of tocotrienols in experimental model systems and humans. This article constitutes an in-depth review of the pharmacology, metabolism, toxicology and biosafety aspects of tocotrienols. Tocotrienols are detectable at appreciable levels in the plasma after supplementations. However, there is inadequate data on the plasma concentrations of tocotrienols that are sufficient to demonstrate significant physiological effect and biodistribution studies show their accumulation in vital organs of the body. Considering the wide range of benefits that tocotrienols possesses against some common human ailments and having a promising potential, the experimental analysis accounts for about a small fraction of all vitamin E research. The current state of knowledge deserves further investigation into this lesser known form of vitamin E.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 369 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Malaysia 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
United States 1 <1%
Unknown 364 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 74 20%
Student > Ph. D. Student 44 12%
Researcher 44 12%
Student > Master 36 10%
Student > Postgraduate 20 5%
Other 60 16%
Unknown 91 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 18%
Medicine and Dentistry 63 17%
Biochemistry, Genetics and Molecular Biology 45 12%
Pharmacology, Toxicology and Pharmaceutical Science 27 7%
Chemistry 16 4%
Other 44 12%
Unknown 109 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#4,805,145
of 16,529,713 outputs
Outputs from Nutrition & Metabolism
#357
of 798 outputs
Outputs of similar age
#63,962
of 235,093 outputs
Outputs of similar age from Nutrition & Metabolism
#1
of 1 outputs
Altmetric has tracked 16,529,713 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 798 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them