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The role of the LRRK2 gene in Parkinsonism

Overview of attention for article published in Molecular Neurodegeneration, November 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
6 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
364 Mendeley
citeulike
2 CiteULike
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Title
The role of the LRRK2 gene in Parkinsonism
Published in
Molecular Neurodegeneration, November 2014
DOI 10.1186/1750-1326-9-47
Pubmed ID
Abstract

Parkinson's disease (PD), like many common age-related conditions, has been recognized to have a substantial genetic component. Multiple lines of evidence suggest that Leucine-rich repeat kinase 2 (LRRK2) is a crucial factor to understanding the etiology of PD. LRRK2 is a large, widely expressed, multi-domain and multifunctional protein. LRRK2 mutations are the major cause to inherited and sporadic PD. In this review, we discuss the pathology and clinical features which show diversity and variability of LRRK2-associated PD. In addition, we do a thorough literature review and provide theoretical data for gene counseling. Further, we present the evidence linking LRRK2 to various possible pathogenic mechanism of PD such as α-synuclein, tau, inflammatory response, oxidative stress, mitochondrial dysfunction, synaptic dysfunction as well as autophagy-lysosomal system. Based on the above work, we investigate activities both within GTPase and outside enzymatic regions in order to obtain a potential therapeutic approach to solve the LRRK2 problem.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 364 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Turkey 1 <1%
United Kingdom 1 <1%
France 1 <1%
Unknown 359 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 86 24%
Student > Ph. D. Student 72 20%
Student > Master 62 17%
Researcher 40 11%
Student > Doctoral Student 20 5%
Other 40 11%
Unknown 44 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 98 27%
Neuroscience 68 19%
Agricultural and Biological Sciences 55 15%
Medicine and Dentistry 33 9%
Pharmacology, Toxicology and Pharmaceutical Science 14 4%
Other 40 11%
Unknown 56 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2015.
All research outputs
#1,866,826
of 8,702,492 outputs
Outputs from Molecular Neurodegeneration
#206
of 434 outputs
Outputs of similar age
#45,741
of 201,585 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 17 outputs
Altmetric has tracked 8,702,492 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 434 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,585 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.