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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of the LRRK2 gene in Parkinsonism
|
|---|---|
| Published in |
Molecular Neurodegeneration, November 2014
|
| DOI | 10.1186/1750-1326-9-47 |
| Pubmed ID | |
| Authors |
Jie-Qiong Li, Lan Tan, Jin-Tai Yu |
| Abstract |
Parkinson's disease (PD), like many common age-related conditions, has been recognized to have a substantial genetic component. Multiple lines of evidence suggest that Leucine-rich repeat kinase 2 (LRRK2) is a crucial factor to understanding the etiology of PD. LRRK2 is a large, widely expressed, multi-domain and multifunctional protein. LRRK2 mutations are the major cause to inherited and sporadic PD. In this review, we discuss the pathology and clinical features which show diversity and variability of LRRK2-associated PD. In addition, we do a thorough literature review and provide theoretical data for gene counseling. Further, we present the evidence linking LRRK2 to various possible pathogenic mechanism of PD such as α-synuclein, tau, inflammatory response, oxidative stress, mitochondrial dysfunction, synaptic dysfunction as well as autophagy-lysosomal system. Based on the above work, we investigate activities both within GTPase and outside enzymatic regions in order to obtain a potential therapeutic approach to solve the LRRK2 problem. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 50% |
| United States | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 498 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Turkey | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 494 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 99 | 20% |
| Student > Ph. D. Student | 91 | 18% |
| Student > Master | 74 | 15% |
| Researcher | 51 | 10% |
| Other | 21 | 4% |
| Other | 51 | 10% |
| Unknown | 111 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 127 | 26% |
| Neuroscience | 78 | 16% |
| Agricultural and Biological Sciences | 60 | 12% |
| Medicine and Dentistry | 38 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 4% |
| Other | 52 | 10% |
| Unknown | 125 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2022.
All research outputs
#2,725,528
of 25,402,889 outputs
Outputs from Molecular Neurodegeneration
#375
of 977 outputs
Outputs of similar age
#30,850
of 271,026 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 18 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,026 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.