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New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut

Overview of attention for article published in npj Biofilms and Microbiomes, November 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
25 tweeters
facebook
1 Facebook page

Citations

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7 Dimensions

Readers on

mendeley
20 Mendeley
Title
New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut
Published in
npj Biofilms and Microbiomes, November 2017
DOI 10.1038/s41522-017-0039-9
Pubmed ID
Authors

Xiaoling Qiang, Anthony S. Liotta, Joseph Shiloach, J. C. Gutierrez, Haichao Wang, Mahendar Ochani, Kanta Ochani, Huan Yang, Aviva Rabin, Derek LeRoith, Maxine A. Lesniak, Markus Böhm, Christian Maaser, Klaus Kannengiesser, Mark Donowitz, Shervin Rabizadeh, Christopher J. Czura, Kevin J. Tracey, Mark Westlake, Aida Zarfeshani, Syed F. Mehdi, Ann Danoff, Xueliang Ge, Suparna Sanyal, Gary J. Schwartz, Jesse Roth

Abstract

E. coli releases a 33 amino acid peptide melanocortin-like peptide of E. coli (MECO-1) that is identical to the C-terminus of the E. coli elongation factor-G (EF-G) and has interesting similarities to two prominent mammalian melanocortin hormones, alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH). Note that MECO-1 lacks HFRW, the common pharmacophore of the known mammalian melanocortin peptides. MECO-1 and the two hormones were equally effective in severely blunting release of cytokines (HMGB1 and TNF) from macrophage-like cells in response to (i) endotoxin (lipopolysaccharide) or (ii) pro-inflammatory cytokine HMGB-1. The in vitro anti-inflammatoty effects of MECO-1 and of alpha-MSH were abrogated by (i) antibody against melanocortin-1 receptor (MC1R) and by (ii) agouti, an endogenous inverse agonist of MC1R. In vivo MECO-1 was even more potent than alpha-MSH in rescuing mice from death due to (i) lethal doses of LPS endotoxin or (ii) cecal ligation and puncture, models of sterile and infectious sepsis, respectively.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 30%
Unspecified 5 25%
Professor 3 15%
Student > Bachelor 3 15%
Student > Doctoral Student 1 5%
Other 2 10%
Readers by discipline Count As %
Unspecified 7 35%
Biochemistry, Genetics and Molecular Biology 3 15%
Neuroscience 3 15%
Agricultural and Biological Sciences 2 10%
Psychology 1 5%
Other 4 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2018.
All research outputs
#1,441,735
of 13,865,005 outputs
Outputs from npj Biofilms and Microbiomes
#67
of 137 outputs
Outputs of similar age
#50,640
of 314,753 outputs
Outputs of similar age from npj Biofilms and Microbiomes
#19
of 34 outputs
Altmetric has tracked 13,865,005 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 137 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.5. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,753 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.