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Primary Liver Cells Cultured on Carbon Nanotube Substrates for Liver Tissue Engineering and Drug Discovery Applications

Overview of attention for article published in ACS Applied Materials & Interfaces, June 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

twitter
3 tweeters

Citations

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17 Dimensions

Readers on

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29 Mendeley
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Title
Primary Liver Cells Cultured on Carbon Nanotube Substrates for Liver Tissue Engineering and Drug Discovery Applications
Published in
ACS Applied Materials & Interfaces, June 2014
DOI 10.1021/am5018489
Pubmed ID
Authors

Che Azurahanim Che Abdullah, Chihye Lewis Azad, Raquel Ovalle-Robles, Shaoli Fang, Marcio D. Lima, Xavier Lepró, Steve Collins, Ray H. Baughman, Alan B. Dalton, Nick J. Plant, Richard P. Sear

Abstract

Here, we explore the use of two- and three-dimensional scaffolds of multiwalled-carbon nanotubes (MWNTs) for hepatocyte cell culture. Our objective is to study the use of these scaffolds in liver tissue engineering and drug discovery. In our experiments, primary rat hepatocytes, the parenchymal (main functional) cell type in the liver, were cultured on aligned nanogrooved MWNT sheets, MWNT yarns, or standard 2-dimensional culture conditions as a control. We find comparable cell viability between all three culture conditions but enhanced production of the hepatocyte-specific marker albumin for cells cultured on MWNTs. The basal activity of two clinically relevant cytochrome P450 enzymes, CYP1A2 and CYP3A4, are similar on all substrates, but we find enhanced induction of CYP1A2 for cells on the MWNT sheets. Our data thus supports the use of these substrates for applications including tissue engineering and enhancing liver-specific functions, as well as in in vitro model systems with enhanced predictive capability in drug discovery and development.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 45%
Researcher 4 14%
Student > Bachelor 3 10%
Professor 2 7%
Lecturer > Senior Lecturer 1 3%
Other 4 14%
Unknown 2 7%
Readers by discipline Count As %
Materials Science 8 28%
Engineering 5 17%
Agricultural and Biological Sciences 3 10%
Medicine and Dentistry 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 5 17%
Unknown 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2014.
All research outputs
#1,647,086
of 4,510,149 outputs
Outputs from ACS Applied Materials & Interfaces
#222
of 1,565 outputs
Outputs of similar age
#36,917
of 116,499 outputs
Outputs of similar age from ACS Applied Materials & Interfaces
#24
of 160 outputs
Altmetric has tracked 4,510,149 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 1,565 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.