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Transient cardiomyocyte fusion regulates cardiac development in zebrafish

Overview of attention for article published in Nature Communications, November 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

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4 news outlets
blogs
1 blog
twitter
16 X users

Citations

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22 Dimensions

Readers on

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94 Mendeley
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Title
Transient cardiomyocyte fusion regulates cardiac development in zebrafish
Published in
Nature Communications, November 2017
DOI 10.1038/s41467-017-01555-8
Pubmed ID
Authors

Suphansa Sawamiphak, Zacharias Kontarakis, Alessandro Filosa, Sven Reischauer, Didier Y. R. Stainier

Abstract

Cells can sacrifice their individuality by fusing, but the prevalence and significance of this process are poorly understood. To approach these questions, here we generate transgenic reporter lines in zebrafish to label and specifically ablate fused cells. In addition to skeletal muscle cells, the reporters label cardiomyocytes starting at an early developmental stage. Genetic mosaics generated by cell transplantation show cardiomyocytes expressing both donor- and host-derived transgenes, confirming the occurrence of fusion in larval hearts. These fusion events are transient and do not generate multinucleated cardiomyocytes. Functionally, cardiomyocyte fusion correlates with their mitotic activity during development as well as during regeneration in adult animals. By analyzing the cell fusion-compromised jam3b mutants, we propose a role for membrane fusion in cardiomyocyte proliferation and cardiac function. Together, our findings uncover the previously unrecognized process of transient cardiomyocyte fusion and identify its potential role in cardiac development and function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 94 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 21%
Student > Master 13 14%
Researcher 11 12%
Student > Bachelor 10 11%
Professor > Associate Professor 6 6%
Other 11 12%
Unknown 23 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 33 35%
Agricultural and Biological Sciences 21 22%
Medicine and Dentistry 6 6%
Neuroscience 3 3%
Social Sciences 2 2%
Other 5 5%
Unknown 24 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2018.
All research outputs
#950,678
of 24,859,977 outputs
Outputs from Nature Communications
#15,489
of 54,282 outputs
Outputs of similar age
#19,498
of 331,185 outputs
Outputs of similar age from Nature Communications
#464
of 1,459 outputs
Altmetric has tracked 24,859,977 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 54,282 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,185 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1,459 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.