Title |
Controlling Streptococcus mutans and Staphylococcus aureus biofilms with direct current and chlorhexidine
|
---|---|
Published in |
AMB Express, November 2017
|
DOI | 10.1186/s13568-017-0505-z |
Pubmed ID | |
Authors |
Hao Wang, Dacheng Ren |
Abstract |
Microbial biofilms formed on biomaterials are major causes of chronic infections. Among them, Gram-positive bacteria Streptococcus mutans and Staphylococcus aureus are important pathogens causing infections associated with dental caries (tooth-decay) and other medical implants. Unfortunately, current antimicrobial approaches are ineffective in disrupting established biofilms and new methods are needed to improve the efficacy. In this study, we report that the biofilm cells of S. mutans and S. aureus can be effectively killed by low-level direct current (DC) and through synergy in concurrent treatment with DC and chlorhexidine (CHX) at low concentrations. For example, after treatment with 28 µA/cm(2) DC and 50 µg/mL CHX for 1 h, the viability of biofilm cells was reduced by approximately 4 and 5 logs for S. mutans and S. aureus, respectively. These results are useful for developing more effective approaches to control pathogenic biofilms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 111 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 17 | 15% |
Student > Ph. D. Student | 14 | 13% |
Student > Master | 10 | 9% |
Student > Doctoral Student | 6 | 5% |
Researcher | 6 | 5% |
Other | 10 | 9% |
Unknown | 48 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 24% |
Agricultural and Biological Sciences | 11 | 10% |
Immunology and Microbiology | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Chemistry | 3 | 3% |
Other | 9 | 8% |
Unknown | 49 | 44% |