↓ Skip to main content

Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment

Overview of attention for article published in BMC Microbiology, November 2014
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
10 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment
Published in
BMC Microbiology, November 2014
DOI 10.1186/s12866-014-0273-8
Pubmed ID
Authors

Chunhe Guo, Yumao Huang, Peiqing Cong, Xiaohong Liu, Yaosheng Chen, Zuyong He

Abstract

BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is a continuous threat to the pig industry, causing high economic losses worldwide. Current vaccines have specific limitations in terms of their safety and efficacy, so the development of novel antiviral drugs is urgently required. The aim of this study was to evaluate the inhibitory effects and underlying molecular mechanisms of the antimicrobial peptide cecropin P1 (CP1) against PRRSV infection in vitro.ResultsCP1 not only displayed extracellular virucidal activity against PRRSV, but also exerted a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation. The inhibitory effect of CP1 occurred during viral attachment, but not at viral entry into Marc-145 cells. CP1 also inhibited viral particle release and attenuated virus-induced apoptosis during the late phase of infection. CP1 exerted similar inhibitory effects against PRRSV infection in porcine alveolar macrophages, the cells targeted by the virus in vivo during its infection of pigs. The expression of interleukin 6 was elevated by CP1 in porcine alveolar macrophages, which might contribute to its inhibition of PRRSV infection.ConclusionsCollectively, our findings provide a new direction for the development of potential therapeutic drugs against PRRSV infection.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 30%
Student > Ph. D. Student 2 20%
Student > Bachelor 1 10%
Researcher 1 10%
Lecturer > Senior Lecturer 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Veterinary Science and Veterinary Medicine 1 10%
Biochemistry, Genetics and Molecular Biology 1 10%
Immunology and Microbiology 1 10%
Engineering 1 10%
Other 0 0%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2014.
All research outputs
#3,672,993
of 4,531,279 outputs
Outputs from BMC Microbiology
#755
of 906 outputs
Outputs of similar age
#108,426
of 139,044 outputs
Outputs of similar age from BMC Microbiology
#41
of 47 outputs
Altmetric has tracked 4,531,279 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 906 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,044 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.