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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii
|
|---|---|
| Published in |
Annals of Clinical Microbiology and Antimicrobials, November 2017
|
| DOI | 10.1186/s12941-017-0248-3 |
| Pubmed ID | |
| Authors |
Kevin M. Raible, Bhaswati Sen, Nancy Law, Tiffany E. Bias, Christopher L. Emery, Garth D. Ehrlich, Suresh G. Joshi |
| Abstract |
Acinetobacter baumannii is a nosocomial pathogen which is establishing as a major cause of morbidity and mortality within the healthcare community. The success of this pathogen is largely due to its ability to rapidly gain resistance to antimicrobial therapies and its capability to persist in an abiotic environment through the production of a biofilm. Our tertiary-care hospital has showed high incidence of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. In this study we explore both genotypic and phenotypic properties of 26 CRAB isolates: 16 isolates were collected from January 2010 to March 2011, and 10 were collected between February and May 2015. We determined that all 26 CRAB isolates possessed multiple β-lactamase genes, including genes from Groups A, C, and D. Specifically, 42% of the isolates possesses the potentially plasmid-borne genes of OXA-23-like or OXA-40-like β-lactamase. The presence of mobile gene element integron cassettes and/or integrases in 88% of the isolates suggests a possible mechanism of dissemination of antibiotic resistance genes. Additionally, the location of insertion sequence (IS) ISAba1 in promotor region of of the OXA-51-like, ADC-7, and ampC genes was confirmed. Multilocus sequence typing (MLST) demonstrated that all 26 CRAB isolates were either sequence type (ST)-229 or ST-2. Interestingly, ST-2 went from being the minority CRAB strain in the 2010-2011 isolates to the predominant strain in the 2015 isolates (from 32 to 90%). We show that the ST-2 strains have an enhanced ability to produce biofilms in comparison to the ST-229 strains, and this fact has potentially led to more successful colonization of the clinical environment over time. This study provides a longitudinal genetic and phenotypic survey of two CRAB sequence types, and suggests how their differing phenotypes may interact with the selective pressures of a hospital setting effecting strain dominance over a 5-year period. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 17% |
| Venezuela, Bolivarian Republic of | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 16% |
| Student > Ph. D. Student | 9 | 13% |
| Researcher | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Student > Doctoral Student | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 27 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 14% |
| Immunology and Microbiology | 7 | 10% |
| Agricultural and Biological Sciences | 5 | 7% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 27 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#13,573,826
of 23,008,860 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#236
of 611 outputs
Outputs of similar age
#148,840
of 294,547 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#4
of 11 outputs
Altmetric has tracked 23,008,860 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 611 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,547 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.