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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study
|
|---|---|
| Published in |
JCEM, November 2014
|
| DOI | 10.1210/jc.2014-2291 |
| Pubmed ID | |
| Authors |
Manfredi Rizzo, Nicola Abate, Manisha Chandalia, Ali A. Rizvi, Rosaria V. Giglio, Dragana Nikolic, Antonella Marino Gammazza, Ignazio Barbagallo, Esma R. Isenovic, Maciej Banach, Giuseppe Montalto, Giovanni Li Volti |
| Abstract |
Context: Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated. Objective: We evaluated the impact of liraglutide on markers of oxidative stress, heme oxygenase-1 (HO-1), and plasma ghrelin levels in patients with type-2 diabetes (T2DM). Design and setting: A prospective pilot study of two months' duration performed at the Unit of Diabetes and Cardiovascular Prevention at University of Palermo, Italy. Patients and Intervention(s): 20 subjects with T2DM (10 men and 10 women, mean age: 57±13 years) were treated with liraglutide subcutaneously (0.6mg/daily for 2 weeks, followed by 1.2mg/daily) in addition to metformin (1500 mg/daily orally) for 2 months. Patients with liver disorders or renal failure were excluded. Main Outcome Measure(s): Plasma ghrelin concentrations, oxidative stress markers, and heat-shock proteins, including HO-1. Results: The addition of liraglutide resulted in a significant decrease in glycated hemoglobin (HbA1c) (8.5±0.4 vs. 7.5±0.4%, p<0.0001). In addition, plasma ghrelin and glutathione (GSH) concentrations increased (8.2±4.1 vs. 13.6±7.3 pg/ml, p=0.0007 and 0.36±0.06 vs. 0.44±0.07 nmol/ml, p=0.0002, respectively), while serum lipid hydroperoxides and HO-1 decreased (0.11±0.05 vs. 0.04±0.07 pg/ml, p=0.0487 and 7.7±7.7 vs. 3.6±1.8 pg/ml, p=0.0445, respectively). These changes were not correlated with changes in fasting glycemia or HbA1c. Conclusions: In a 2-months prospective pilot study, the addition of liraglutide to metformin resulted in improvement in oxidative stress as well as plasma ghrelin and HO-1 concentrations in patients with T2DM. These findings appeared to be independent of the known effects of liraglutide on glucose metabolism. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 17% |
| Student > Bachelor | 13 | 13% |
| Researcher | 12 | 12% |
| Student > Ph. D. Student | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 16 | 16% |
| Unknown | 29 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 25% |
| Agricultural and Biological Sciences | 8 | 8% |
| Nursing and Health Professions | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Other | 13 | 13% |
| Unknown | 35 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2022.
All research outputs
#2,299,291
of 25,394,764 outputs
Outputs from JCEM
#1,804
of 15,434 outputs
Outputs of similar age
#25,973
of 270,464 outputs
Outputs of similar age from JCEM
#24
of 165 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,434 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.