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PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, February 2009
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Title
PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
Published in
Proceedings of the National Academy of Sciences of the United States of America, February 2009
DOI 10.1073/pnas.0808801106
Pubmed ID
Authors

Kathleen A. O'Hagan, Sinead Cocchiglia, Alexander V. Zhdanov, Murtaza M. Tambuwala, Eoin P. Cummins, Mona Monfared, Terence A. Agbor, John F. Garvey, Dmitri B. Papkovsky, Cormac T. Taylor, Bernard B. Allan

Abstract

Mitochondrial biogenesis occurs in response to increased cellular ATP demand. The mitochondrial electron transport chain requires molecular oxygen to produce ATP. Thus, increased ATP generation after mitochondrial biogenesis results in increased oxygen demand that must be matched by a corresponding increase in oxygen supply. We found that overexpression of peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), which increases mitochondrial biogenesis in primary skeletal muscle cells, leads to increased expression of a cohort of genes known to be regulated by the dimeric hypoxia-inducible factor (HIF), a master regulator of the adaptive response to hypoxia. PGC-1alpha-dependent induction of HIF target genes under physiologic oxygen concentrations is not through transcriptional coactivation of HIF or up-regulation of HIF-1alpha mRNA but through HIF-1alpha protein stabilization. It occurs because of intracellular hypoxia as a result of increased oxygen consumption after mitochondrial biogenesis. Thus, we propose that at physiologic oxygen concentrations, PGC-1alpha is coupled to HIF signaling through the regulation of intracellular oxygen availability, allowing cells and tissues to match increased oxygen demand after mitochondrial biogenesis with increased oxygen supply.

Mendeley readers

The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Korea, Republic of 1 <1%
India 1 <1%
Iran, Islamic Republic of 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 167 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 30%
Researcher 32 18%
Student > Master 21 12%
Professor 14 8%
Student > Bachelor 12 7%
Other 27 15%
Unknown 17 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 69 39%
Biochemistry, Genetics and Molecular Biology 30 17%
Medicine and Dentistry 26 15%
Sports and Recreations 6 3%
Neuroscience 4 2%
Other 14 8%
Unknown 26 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2014.
All research outputs
#20,243,777
of 22,771,140 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#96,204
of 98,228 outputs
Outputs of similar age
#90,387
of 93,966 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#666
of 671 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 98,228 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,966 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 671 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.