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Synthetic Biology – Metabolic Engineering

Overview of attention for book
Attention for Chapter 3: Synthetic Biology of Polyhydroxyalkanoates (PHA)
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 225)
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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7 X users
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1 patent

Citations

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9 Dimensions

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76 Mendeley
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Chapter title
Synthetic Biology of Polyhydroxyalkanoates (PHA)
Chapter number 3
Book title
Advances in Biochemical Engineering/Biotechnology
Published in
Advances in biochemical engineering biotechnology, June 2017
DOI 10.1007/10_2017_3
Pubmed ID
Book ISBNs
978-3-31-955317-7, 978-3-31-955318-4
Authors

Meng, De-Chuan, Chen, Guo-Qiang, De-Chuan Meng, Guo-Qiang Chen

Abstract

Microbial polyhydroxyalkanoates (PHA) are a family of biodegradable and biocompatible polyesters which have been extensively studied using synthetic biology and metabolic engineering methods for improving production and for widening its diversity. Synthetic biology has allowed PHA to become composition controllable random copolymers, homopolymers, and block copolymers. Recent developments showed that it is possible to establish a microbial platform for producing not only random copolymers with controllable monomers and their ratios but also structurally defined homopolymers and block copolymers. This was achieved by engineering the genome of Pseudomonas putida or Pseudomonas entomophiles to weaken the β-oxidation and in situ fatty acid synthesis pathways, so that a fatty acid fed to the bacteria maintains its original chain length and structures when incorporated into the PHA chains. The engineered bacterium allows functional groups in a fatty acid to be introduced into PHA, forming functional PHA, which, upon grafting, generates endless PHA variety. Recombinant Escherichia coli also succeeded in producing efficiently poly(3-hydroxypropionate) or P3HP, the strongest member of PHA. Synthesis pathways of P3HP and its copolymer P3HB3HP of 3-hydroxybutyrate and 3-hydroxypropionate were assembled respectively to allow their synthesis from glucose. CRISPRi was also successfully used to manipulate simultaneously multiple genes and control metabolic flux in E. coli to obtain a series of copolymer P3HB4HB of 3-hydroxybutyrate (3HB) and 4-hydroxybutyrate (4HB). The bacterial shapes were successfully engineered for enhanced PHA accumulation.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Student > Master 13 17%
Student > Bachelor 10 13%
Researcher 8 11%
Other 5 7%
Other 7 9%
Unknown 20 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 29%
Agricultural and Biological Sciences 9 12%
Chemistry 8 11%
Immunology and Microbiology 6 8%
Chemical Engineering 3 4%
Other 4 5%
Unknown 24 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2021.
All research outputs
#5,222,206
of 24,998,746 outputs
Outputs from Advances in biochemical engineering biotechnology
#31
of 225 outputs
Outputs of similar age
#84,498
of 321,911 outputs
Outputs of similar age from Advances in biochemical engineering biotechnology
#1
of 5 outputs
Altmetric has tracked 24,998,746 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 225 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them