Title |
Reduction of n-3 PUFAs, specifically DHA and EPA, and enhancement of peroxisomal beta-oxidation in type 2 diabetic rat heart
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Published in |
Cardiovascular Diabetology, October 2012
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DOI | 10.1186/1475-2840-11-126 |
Pubmed ID | |
Authors |
Lianguo Hou, Kaoqi Lian, Min Yao, Yun Shi, Xin Lu, Lijia Fang, Tianbo He, Lingling Jiang |
Abstract |
There is overwhelming evidence that dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs), mainly EPA (C20:5n-3) and DHA (C22:6n-3), has cardiovascular protective effects on patients with type 2 diabetes mellitus (T2DM) but not on healthy people. Because the T2DM heart increases fatty acid oxidation (FAO) to compensate for the diminished utilization of glucose, we hypothesize that T2DM hearts consume more n-3 PUFAs and, therefore, need more n-3 PUFAs. In the present study, we investigated the changes in cardiac n-3 PUFAs and peroxisomal beta-oxidation, which are responsible for the degradation of PUFAs in a high-fat diet (HFD) and low-dose streptozotocin- (STZ) induced type 2 diabetic rat model. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 18% |
Student > Ph. D. Student | 5 | 15% |
Student > Master | 5 | 15% |
Other | 3 | 9% |
Student > Bachelor | 2 | 6% |
Other | 6 | 18% |
Unknown | 7 | 21% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 26% |