Advances in vascular thiol isomerase function

https://t.co/M5CJR4ty3P "These results support a model whereby ingestion of isoquercetin causes inhibition of PDI, impairing the conversion of factor V to Va and thereby limiting thrombin generation."

https://t.co/M5CJR4ty3P "To evaluate the mechanism by which inhibition of PDI blocks thrombin generation, the authors evaluated the effect of isoquercetin on factor V activation." "They showed that PDI inhibition blocks generation of factor Va in platele

https://t.co/M5CJR4ty3P "The inhibitory effect of PDI inhibition by isoquercetin was even more marked in patients with antiphospholipid syndrome."

https://t.co/M5CJR4ty3P "Ingestion of isoquercetin also inhibited platelet-dependent thrombin generation." "This inhibition could be overcome by addition of recombinant PDI to the assay, indicating that isoquercetin was acting via inhibition of PDI."