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Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

Overview of attention for article published in Arthritis & Rheumatology, February 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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Title
Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis
Published in
Arthritis & Rheumatology, February 2015
DOI 10.1002/art.38967
Pubmed ID
Authors

Mary-Ellen Costello, Francesco Ciccia, Dana Willner, Nicole Warrington, Philip C. Robinson, Brooke Gardiner, Mhairi Marshall, Tony J. Kenna, Giovanni Triolo, Matthew A. Brown

Abstract

Objective. Ankylosing spondylitis (AS) is a common highly heritable immune mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitous environmental trigger. There is a close relationship between the gut and SpA, exemplified in reactive arthritis patients where a typically self-limiting arthropathy follows either gastrointestinal or urogenital infection. Microbial involvement has been suggested in AS, however, no definitive link has been established. We sought to determine if the AS gut carries a distinct microbial signature, in comparison to healthy controls (HC). Methods. Microbial profiles from terminal ileal (TI) biopsies from subjects with recent-onset, TNF-antagonist naïve AS and HC, were generated using culture-independent 16S rRNA gene sequencing and analysis techniques. Results. Our results show the TI microbial communities of patients with AS differ significantly (P<0.001) from HC, driven by higher abundance of five families of bacteria Lachnospiraceae (P=0.001), Veillonellaceae (P=0.01), Prevotellaceae (P=0.004), Porphyromonadaceae (P=0.001), and Bacteroidaceae (P=0.001); two of which, Lachnospiracecae, and Prevotellaceace, have been strongly associated with colitis and CD. Conclusions. We show evidence for a discrete microbial signature in the TI of cases with AS compared to HC. The microbial composition was found to correlate with disease status and greater differences were observed between than within disease groups. These results are consistent with the hypothesis that genes associated with AS act at least in part through effects on the gut microbiome. This article is protected by copyright. All rights reserved.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 1%
United Kingdom 1 1%
South Africa 1 1%
United States 1 1%
Unknown 82 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 20%
Student > Ph. D. Student 16 19%
Student > Master 15 17%
Student > Bachelor 9 10%
Other 8 9%
Other 21 24%
Readers by discipline Count As %
Medicine and Dentistry 39 45%
Agricultural and Biological Sciences 20 23%
Biochemistry, Genetics and Molecular Biology 11 13%
Unspecified 9 10%
Immunology and Microbiology 6 7%
Other 1 1%

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2017.
All research outputs
#342,573
of 12,354,690 outputs
Outputs from Arthritis & Rheumatology
#69
of 826 outputs
Outputs of similar age
#8,728
of 269,004 outputs
Outputs of similar age from Arthritis & Rheumatology
#7
of 78 outputs
Altmetric has tracked 12,354,690 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 826 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,004 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.