↓ Skip to main content

Changes in liver function and body composition by direct-acting antiviral therapy for hepatitis C virus infection

Overview of attention for article published in Hepatology Research, December 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 478)
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

news
1 news outlet

Readers on

mendeley
7 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Changes in liver function and body composition by direct-acting antiviral therapy for hepatitis C virus infection
Published in
Hepatology Research, December 2017
DOI 10.1111/hepr.12999
Pubmed ID
Authors

Ryosuke Sugimoto, Motoh Iwasa, Nagisa Hara, Yasuyuki Tamai, Kyoko Yoshikawa, Suguru Ogura, Hideaki Tanaka, Akiko Eguchi, Norihiko Yamamoto, Yoshinao Kobayashi, Hiroshi Hasegawa, Yoshiyuki Takei

Abstract

Management of low skeletal muscle mass (LSM) is a very important topic since LSM affects patient mortality in liver diseases. Changes in body composition are unexplored in chronic hepatitis C virus (HCV) patients, including those with liver cirrhosis, who receive direct-acting antiviral (DAA) therapy. Body composition measurements and liver function tests were performed before and after DAA therapy. Blood examination, visceral fat area (VFA) and extremity skeletal muscle mass were measured using the multi-frequency bioelectrical impedance analysis method: i) at 24 weeks pre DAA therapy; ii) at the start of DAA therapy; iii) at the end of DAA therapy; iv) at 24 weeks post DAA therapy; and v) at 48 weeks post DAA therapy. Serum albumin (Alb) levels were significantly increased at 48 weeks post DAA therapy, especially in patients with LSM. Skeletal muscle mass index (SMI) was significantly increased after DAA therapy (at 24 weeks and 48 weeks post DAA therapy) in patients with LSM (p<0.05). An increase in SMI was associated with an increase in body weight or a decrease in VFA. We continuously measured body composition in HCV infected patients who received DAA therapy and found that skeletal muscle mass was significantly increased, associated with an elevation of serum Alb levels and/or body weight or reduction in VFA, but only in patients who presented with LSM before DAA therapy.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Unknown 7 100%
Readers by discipline Count As %
Unknown 7 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2017.
All research outputs
#1,865,482
of 12,253,551 outputs
Outputs from Hepatology Research
#20
of 478 outputs
Outputs of similar age
#73,696
of 342,087 outputs
Outputs of similar age from Hepatology Research
#4
of 19 outputs
Altmetric has tracked 12,253,551 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 478 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.