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SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

Overview of attention for article published in Molecular Neurodegeneration, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 530)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
patent
2 patents
facebook
1 Facebook page

Citations

dimensions_citation
86 Dimensions

Readers on

mendeley
120 Mendeley

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Title
SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease
Published in
Molecular Neurodegeneration, January 2014
DOI 10.1186/1750-1326-9-53
Pubmed ID
25418885
Authors

Ann Brinkmalm, Gunnar Brinkmalm, William G Honer, Lutz Frölich, Lucrezia Hausner, Lennart Minthon, Oskar Hansson, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Annika Öhrfelt

Abstract

Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic proteins such as synaptotagmin and synaptosomal-associated protein 25 (SNAP-25) could be detected in pooled samples of cerebrospinal fluid, however these assays were not sensitive enough for individual samples.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Belgium 1 <1%
Unknown 117 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 28%
Student > Ph. D. Student 26 22%
Student > Master 11 9%
Student > Doctoral Student 8 7%
Student > Bachelor 6 5%
Other 21 18%
Unknown 15 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 20%
Neuroscience 23 19%
Medicine and Dentistry 22 18%
Biochemistry, Genetics and Molecular Biology 8 7%
Psychology 3 3%
Other 13 11%
Unknown 27 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2017.
All research outputs
#761,821
of 12,114,099 outputs
Outputs from Molecular Neurodegeneration
#32
of 530 outputs
Outputs of similar age
#20,591
of 274,383 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 20 outputs
Altmetric has tracked 12,114,099 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 530 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,383 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.

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