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The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis

Overview of attention for article published in BMC Biology, January 2009
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  • Average Attention Score compared to outputs of the same age

Mentioned by

peer_reviews
1 peer review site

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
41 Mendeley
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Title
The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
Published in
BMC Biology, January 2009
DOI 10.1186/1741-7007-7-24
Pubmed ID
Authors

Eusebio Chiefari, Francesco Paonessa, Stefania Iiritano, Ilaria Le Pera, Dario Palmieri, Giuseppe Brunetti, Angelo Lupo, Vittorio Colantuoni, Daniela Foti, Elio Gulletta, Giovambattista De Sarro, Alfredo Fusco, Antonio Brunetti

Abstract

We previously showed that mice lacking the high mobility group A1 gene (Hmga1-knockout mice) developed a type 2-like diabetic phenotype, in which cell-surface insulin receptors were dramatically reduced (below 10% of those in the controls) in the major targets of insulin action, and glucose intolerance was associated with increased peripheral insulin sensitivity. This particular phenotype supports the existence of compensatory mechanisms of insulin resistance that promote glucose uptake and disposal in peripheral tissues by either insulin-dependent or insulin-independent mechanisms. We explored the role of these mechanisms in the regulation of glucose homeostasis by studying the Hmga1-knockout mouse model. Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
China 1 2%
Italy 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 24%
Student > Ph. D. Student 6 15%
Researcher 6 15%
Professor > Associate Professor 5 12%
Professor 4 10%
Other 7 17%
Unknown 3 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 34%
Medicine and Dentistry 10 24%
Biochemistry, Genetics and Molecular Biology 6 15%
Nursing and Health Professions 2 5%
Immunology and Microbiology 1 2%
Other 4 10%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2017.
All research outputs
#4,923,811
of 9,064,896 outputs
Outputs from BMC Biology
#802
of 961 outputs
Outputs of similar age
#122,487
of 244,838 outputs
Outputs of similar age from BMC Biology
#31
of 37 outputs
Altmetric has tracked 9,064,896 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 961 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.