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An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis

Overview of attention for article published in International Journal of Nanomedicine, November 2014
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Title
An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis
Published in
International Journal of Nanomedicine, November 2014
DOI 10.2147/ijn.s68966
Pubmed ID
Authors

Eduardo Coelho, Tatiana Ribeiro, Leonardo Fuscaldi, Mara Santos, Mariana Duarte, Paula Lage, Vivian Martins, Lourena Costa, Simone Diniz, Valbert Cardoso, Rachel Castilho, Manuel Soto, Carlos Alberto Tavares, Miguel Fumagalli, Jucara Ribeiro, Andre Faraco

Abstract

Amphotericin B (AmpB) is active against leishmaniasis, but its use is hampered due to its high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, was evaluated in BALB/c mice against Leishmania amazonensis. An in vivo biodistribution study, including biochemical and toxicological evaluations, was performed to evaluate the toxicity of AmpB. Nanoparticles were radiolabeled with technetium-99m and injected in mice. The products presented a similar biodistribution in the liver, spleen, and kidneys of the animals. Free AmpB induced alterations in the body weight of the mice, which, in the biochemical analysis, indicated hepatic and renal injury, as well as morphological damage to the kidneys of the animals. In general, no significant organic alteration was observed in the animals treated with NQC-AmpB. Mice were infected with L. amazonensis and treated with the nanoparticles or free AmpB; then, parasitological and immunological analyses were performed. The NQC-AmpB group, as compared to the control groups, presented significant reductions in the lesion size and in the parasite burden in all evaluated organs. These animals presented significantly higher levels of IFN-γ and IL-12, and low levels of IL-4 and IL-10, when compared to the control groups. The NQC-AmpB system was effective in reducing the infection in the animals, and proved to be effective in diminishing the toxicity evoked by AmpB, which was observed when it was administered alone. In conclusion, NQC-AmpB could be considered a viable possibility for future studies in the treatment of leishmaniasis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 25%
Student > Bachelor 9 12%
Researcher 9 12%
Student > Ph. D. Student 9 12%
Student > Doctoral Student 6 8%
Other 12 16%
Unknown 10 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 15 21%
Medicine and Dentistry 8 11%
Chemistry 8 11%
Agricultural and Biological Sciences 8 11%
Biochemistry, Genetics and Molecular Biology 7 10%
Other 10 14%
Unknown 17 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2014.
All research outputs
#3,695,308
of 4,559,875 outputs
Outputs from International Journal of Nanomedicine
#944
of 1,158 outputs
Outputs of similar age
#114,774
of 146,463 outputs
Outputs of similar age from International Journal of Nanomedicine
#28
of 36 outputs
Altmetric has tracked 4,559,875 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,158 research outputs from this source. They receive a mean Attention Score of 1.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,463 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.