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Neurotoxic Factors in Parkinson’s Disease and Related Disorders

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Cover of 'Neurotoxic Factors in Parkinson’s Disease and Related Disorders'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms of Selective Toxicity in Neurodegenerative Disorders
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    Chapter 2 The Dopamine Transporter: Involvement in Selective Dopaminergic Neurodegeneration
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    Chapter 3 Advances in our Knowledge of MPTP Action and Mechanism
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    Chapter 4 Role of Microtubules in the Genesis of MPTP Neurotoxicity
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    Chapter 5 Complex I Inhibition in Cultured Cells as Model for Parkinson’s Disease
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    Chapter 6 Nigral Degeneration in Animal Models of Multiple System Atrophy
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    Chapter 7 Isoquinoline Neurotoxins
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    Chapter 8 Apoptosis by an Endogenous Neurotoxin, N -Methyl( R )Salsolinol: Relevance to Parkinson’s Disease
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    Chapter 9 Isoquinolines in Parkinson’s Disease
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    Chapter 10 Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol levels in Various Human Brain Areas
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    Chapter 11 Antidopaminergic Effects of Putative Endogenous MPTP-Like Agents: 1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline
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    Chapter 12 Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson’s Disease Patients
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    Chapter 13 ß -Carboline Analogues of MPP + as Environmental Neurotoxins
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    Chapter 14 N -Methyl- ß -Carbolinium Neurotoxins in Parkinson’s Disease
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    Chapter 15 ‘TaClo’, A Chloral-Derived Mammalian Alkaloid with Neurotoxic Properties
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    Chapter 16 Nutritional Sources of Novel Tetrahydro- ß -Carbolines
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    Chapter 17 Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegeneration
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    Chapter 18 Catecholamine-Derived Aldehyde Neurotoxins
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    Chapter 19 Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and its Oxidative Metabolites in the Pathogenesis of Parkinson’s Disease
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    Chapter 20 Neuromelanin may Mediate Neurotoxicity via its Interaction with Redox Active Iron
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    Chapter 21 bcl-2 Protects SK-N-SH Cells From 6-Hydroxydopamine Induced Apoptosis by Inhibition of Cytochrome c Redistribution
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    Chapter 22 Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson’s Disease
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    Chapter 23 Relationship of Organochlorine Pesticides to Parkinsonism
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    Chapter 24 Paraquat is a Model Environmental Neurotoxin for Studying Parkinson’s Disease
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    Chapter 25 Brain Iron and other Trace Metals in Neurodegenerative Diseases
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    Chapter 26 Contribution of Intracellular Non-Haem Iron, NF- k B Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection
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    Chapter 27 Neurochemical Mechanisms Underlying Neuroprotective Actions of Bromocriptine, Salicylate, d - and L -Deprenyl in Neurodegeneration caused by MPTP
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    Chapter 28 Attenuation of Levodopa-Induced Toxicity in Primary Dopamine Neurons by Catechol- O -Methyltransferase Inhibition
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    Chapter 29 Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB 1 Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implications
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    Chapter 30 Riluzole as a Neuroprotective Therapy in Animal Models of Parkinson’s Disease
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    Chapter 31 Progressive Reduction of the Rat Nigrostriatal Dopamine Metabolism Induced by Iron-III and TaClo
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    Chapter 32 Brain N -Methylation of Indolic ß -Carbolines in Parkinsonism
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    Chapter 33 Deleterious Effects of Highly Halogenated ß -Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration
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    Chapter 34 Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatum
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    Chapter 35 New Taurine Analogues in Treatment Strategies for Parkinson’s Disease
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    Chapter 36 The Neurotoxicity of Manganese
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    Chapter 37 Organotypic Striatal Slices: Neuroprotective Effects of Vitamins
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    Chapter 38 Impairment of Energy Metabolism is not Responsible for Cytotoxicity of 6-Hydroxydopamine towards Human SH-SY5Y Dopaminergic Neuroblastoma Cells
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    Chapter 39 Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro- ß -Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson’s Disease Patients
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    Chapter 40 Chronic Treatment with 1,2,3,4-Tetrahydroiso-Quinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian like Muscle Rigidity in Young and Old Rats
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    Chapter 41 Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N -Methyl( R ) Salsolinol
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    Chapter 42 1-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons
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    Chapter 43 The Effects of Catecholic and O -Methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radical
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    Chapter 44 Differential Cytotoxicity of Isoquinolines in HEK-293 Cells Stably Transfected with the Dopamine Transporter Gene
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    Chapter 45 HEK-293 Cells Expressing the Human Dopamine Transporter are Susceptible to Low Concentrations of 1-Methyl-4-Phenylpyridinium (MPP + ) via Impairment of Energy Metabolism
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    Chapter 46 Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Mice
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    Chapter 47 Neurological Disorders — Acetylcholine Mimics and their Role as Uncompetitive Inhibitors of Esterases
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    Chapter 48 Nicotinic Acetylcholine Receptor Agonist Activity of Isoquinoline Alkaloids
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    Chapter 49 Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro- ß -Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration in Vitro after Toxin Withdrawal
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Neurotoxic Factors in Parkinson’s Disease and Related Disorders
Published by
Springer Science & Business Media, December 2012
DOI 10.1007/978-1-4615-1269-1
978-1-4615-1269-1, 978-0-306-46529-1, 978-1-4613-5470-3

Storch, Alexander, Collins, Michael A.

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 25%
Student > Bachelor 1 13%
Researcher 1 13%
Student > Postgraduate 1 13%
Unknown 3 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Agricultural and Biological Sciences 1 13%
Psychology 1 13%
Neuroscience 1 13%
Unknown 3 38%