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Neurotoxic Factors in Parkinson’s Disease and Related Disorders

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Cover of 'Neurotoxic Factors in Parkinson’s Disease and Related Disorders'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms of Selective Toxicity in Neurodegenerative Disorders
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    Chapter 2 The Dopamine Transporter: Involvement in Selective Dopaminergic Neurodegeneration
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    Chapter 3 Advances in our Knowledge of MPTP Action and Mechanism
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    Chapter 4 Role of Microtubules in the Genesis of MPTP Neurotoxicity
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    Chapter 5 Complex I Inhibition in Cultured Cells as Model for Parkinson’s Disease
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    Chapter 6 Nigral Degeneration in Animal Models of Multiple System Atrophy
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    Chapter 7 Isoquinoline Neurotoxins
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    Chapter 8 Apoptosis by an Endogenous Neurotoxin, N -Methyl( R )Salsolinol: Relevance to Parkinson’s Disease
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    Chapter 9 Isoquinolines in Parkinson’s Disease
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    Chapter 10 Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol levels in Various Human Brain Areas
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    Chapter 11 Antidopaminergic Effects of Putative Endogenous MPTP-Like Agents: 1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline
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    Chapter 12 Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson’s Disease Patients
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    Chapter 13 ß -Carboline Analogues of MPP + as Environmental Neurotoxins
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    Chapter 14 N -Methyl- ß -Carbolinium Neurotoxins in Parkinson’s Disease
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    Chapter 15 ‘TaClo’, A Chloral-Derived Mammalian Alkaloid with Neurotoxic Properties
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    Chapter 16 Nutritional Sources of Novel Tetrahydro- ß -Carbolines
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    Chapter 17 Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegeneration
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    Chapter 18 Catecholamine-Derived Aldehyde Neurotoxins
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    Chapter 19 Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and its Oxidative Metabolites in the Pathogenesis of Parkinson’s Disease
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    Chapter 20 Neuromelanin may Mediate Neurotoxicity via its Interaction with Redox Active Iron
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    Chapter 21 bcl-2 Protects SK-N-SH Cells From 6-Hydroxydopamine Induced Apoptosis by Inhibition of Cytochrome c Redistribution
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    Chapter 22 Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson’s Disease
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    Chapter 23 Relationship of Organochlorine Pesticides to Parkinsonism
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    Chapter 24 Paraquat is a Model Environmental Neurotoxin for Studying Parkinson’s Disease
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    Chapter 25 Brain Iron and other Trace Metals in Neurodegenerative Diseases
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    Chapter 26 Contribution of Intracellular Non-Haem Iron, NF- k B Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection
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    Chapter 27 Neurochemical Mechanisms Underlying Neuroprotective Actions of Bromocriptine, Salicylate, d - and L -Deprenyl in Neurodegeneration caused by MPTP
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    Chapter 28 Attenuation of Levodopa-Induced Toxicity in Primary Dopamine Neurons by Catechol- O -Methyltransferase Inhibition
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    Chapter 29 Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB 1 Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implications
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    Chapter 30 Riluzole as a Neuroprotective Therapy in Animal Models of Parkinson’s Disease
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    Chapter 31 Progressive Reduction of the Rat Nigrostriatal Dopamine Metabolism Induced by Iron-III and TaClo
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    Chapter 32 Brain N -Methylation of Indolic ß -Carbolines in Parkinsonism
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    Chapter 33 Deleterious Effects of Highly Halogenated ß -Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration
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    Chapter 34 Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatum
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    Chapter 35 New Taurine Analogues in Treatment Strategies for Parkinson’s Disease
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    Chapter 36 The Neurotoxicity of Manganese
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    Chapter 37 Organotypic Striatal Slices: Neuroprotective Effects of Vitamins
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    Chapter 38 Impairment of Energy Metabolism is not Responsible for Cytotoxicity of 6-Hydroxydopamine towards Human SH-SY5Y Dopaminergic Neuroblastoma Cells
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    Chapter 39 Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro- ß -Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson’s Disease Patients
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    Chapter 40 Chronic Treatment with 1,2,3,4-Tetrahydroiso-Quinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian like Muscle Rigidity in Young and Old Rats
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    Chapter 41 Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N -Methyl( R ) Salsolinol
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    Chapter 42 1-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons
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    Chapter 43 The Effects of Catecholic and O -Methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radical
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    Chapter 44 Differential Cytotoxicity of Isoquinolines in HEK-293 Cells Stably Transfected with the Dopamine Transporter Gene
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    Chapter 45 HEK-293 Cells Expressing the Human Dopamine Transporter are Susceptible to Low Concentrations of 1-Methyl-4-Phenylpyridinium (MPP + ) via Impairment of Energy Metabolism
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    Chapter 46 Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Mice
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    Chapter 47 Neurological Disorders — Acetylcholine Mimics and their Role as Uncompetitive Inhibitors of Esterases
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    Chapter 48 Nicotinic Acetylcholine Receptor Agonist Activity of Isoquinoline Alkaloids
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    Chapter 49 Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro- ß -Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration in Vitro after Toxin Withdrawal
Attention for Chapter 33: Deleterious Effects of Highly Halogenated ß -Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration
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Chapter title
Deleterious Effects of Highly Halogenated ß -Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration
Chapter number 33
Book title
Neurotoxic Factors in Parkinson’s Disease and Related Disorders
Published by
Springer, Boston, MA, January 2000
DOI 10.1007/978-1-4615-1269-1_33
Book ISBNs
978-1-4613-5470-3, 978-1-4615-1269-1
Authors

G. Gille, B. Janetzky, M. Abdel-Mohsen, R. God, W.-D Rausch, G. Bringmann, H. Reichmann