Title |
Metabolic engineering of Methylobacterium extorquens AM1 for 1-butanol production
|
---|---|
Published in |
Biotechnology for Biofuels and Bioproducts, October 2014
|
DOI | 10.1186/s13068-014-0156-0 |
Pubmed ID | |
Authors |
Bo Hu, Mary E Lidstrom |
Abstract |
Butanol is a promising next generation fuel and a bulk chemical precursor. Although clostridia are the primary industrial microbes for the fermentative production of 1-butanol, alternative engineered hosts have the potential to generate 1-butanol from alternative carbon feedstocks via synthetic metabolic pathways. Methylobacterium extorquens AM1, a facultative methylotrophic α-proteobacterium, is a model system for assessing the possibility of generating products such as 1-butanol from one-carbon and two-carbon feedstocks. Moreover, the core methylotrophic pathways in M. extorquens AM1 involve unusual coenzyme A (CoA)-derivative metabolites, such as crotonyl-CoA, which is a precursor for the production of 1-butanol. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Germany | 1 | <1% |
Indonesia | 1 | <1% |
Portugal | 1 | <1% |
India | 1 | <1% |
Finland | 1 | <1% |
Spain | 1 | <1% |
Romania | 1 | <1% |
Unknown | 123 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 28 | 21% |
Researcher | 26 | 20% |
Student > Ph. D. Student | 22 | 17% |
Student > Bachelor | 15 | 11% |
Other | 8 | 6% |
Other | 17 | 13% |
Unknown | 16 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 38 | 29% |
Biochemistry, Genetics and Molecular Biology | 35 | 27% |
Engineering | 13 | 10% |
Chemistry | 8 | 6% |
Chemical Engineering | 5 | 4% |
Other | 10 | 8% |
Unknown | 23 | 17% |