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Application of positron annihilation lifetime spectroscopy (PALS) to study the nanostructure in amphiphile self-assembly materials: phytantriol cubosomes and hexosomes

Overview of attention for article published in Physical Chemistry Chemical Physics (PCCP), January 2015
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Title
Application of positron annihilation lifetime spectroscopy (PALS) to study the nanostructure in amphiphile self-assembly materials: phytantriol cubosomes and hexosomes
Published in
Physical Chemistry Chemical Physics (PCCP), January 2015
DOI 10.1039/c4cp04343j
Pubmed ID
Authors

Aurelia W. Dong, Celesta Fong, Lynne J. Waddington, Anita J. Hill, Ben J. Boyd, Calum J. Drummond

Abstract

Self-assembled amphiphile nanostructures of colloidal dimensions such as cubosomes and hexosomes are of interest as delivery vectors in pharmaceutical and nanomedicine applications. Translation would be assisted through a better of understanding of the effects of drug loading on the internal nanostructure, and the relationship between this nanostructure and drug release profile. Positron annihilation lifetime spectroscopy (PALS) is sensitive to local microviscosity and is used as an in situ molecular probe to examine the Q2 (cubosome) → H2 (hexosome) → L2 phase transitions of the pharmaceutically relevant phytantriol-water system in the presence of a model hydrophobic drug, vitamin E acetate (VitEA). It is shown that the ortho-positronium lifetime (τ) is sensitive to molecular packing and mobility and this has been correlated with the rheological properties of individual lyotropic liquid crystalline mesophases. Characteristic PALS lifetimes for L2 (τ4 ∼ 4 ns) ∼ H2 (τ4 ∼ 4 ns) > Q2 Pn3m (τ4 ∼ 2.2 ns) are observed for the phytantriol-water system, with the addition of VitEA yielding a gradual increase in τ from τ ∼ 2.2 ns for cubosomes to τ ∼ 3.5 ns for hexosomes. The dynamic chain packing at higher temperatures and in the L2 and H2 phases is qualitatively less "viscous", consistent with rheological measurements. This information offers increased understanding of the relationship between internal nanostructure and species permeability.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 30%
Student > Ph. D. Student 5 25%
Student > Master 2 10%
Student > Doctoral Student 2 10%
Professor 1 5%
Other 3 15%
Unknown 1 5%
Readers by discipline Count As %
Chemistry 8 40%
Engineering 3 15%
Physics and Astronomy 3 15%
Materials Science 2 10%
Medicine and Dentistry 1 5%
Other 2 10%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2015.
All research outputs
#9,860,043
of 12,346,685 outputs
Outputs from Physical Chemistry Chemical Physics (PCCP)
#3,773
of 7,363 outputs
Outputs of similar age
#180,920
of 269,920 outputs
Outputs of similar age from Physical Chemistry Chemical Physics (PCCP)
#79
of 155 outputs
Altmetric has tracked 12,346,685 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,363 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
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We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.