↓ Skip to main content

Optimization of the prescription isodose line for Gamma Knife radiosurgery using the shot within shot technique

Overview of attention for article published in Radiation Oncology, November 2017
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

twitter
1 X user
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
21 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Optimization of the prescription isodose line for Gamma Knife radiosurgery using the shot within shot technique
Published in
Radiation Oncology, November 2017
DOI 10.1186/s13014-017-0919-4
Pubmed ID
Authors

Perry B. Johnson, Maria I. Monterroso, Fei Yang, Eric Mellon

Abstract

This work explores how the choice of prescription isodose line (IDL) affects the dose gradient, target coverage, and treatment time for Gamma Knife radiosurgery when a smaller shot is encompassed within a larger shot at the same stereotactic coordinates (shot within shot technique). Beam profiles for the 4, 8, and 16 mm collimator settings were extracted from the treatment planning system and characterized using Gaussian fits. The characterized data were used to create over 10,000 shot within shot configurations by systematically changing collimator weighting and choice of prescription IDL. Each configuration was quantified in terms of the dose gradient, target coverage, and beam-on time. By analyzing these configurations, it was found that there are regions of overlap in target size where a higher prescription IDL provides equivalent dose fall-off to a plan prescribed at the 50% IDL. Furthermore, the data indicate that treatment times within these regions can be reduced by up to 40%. An optimization strategy was devised to realize these gains. The strategy was tested for seven patients treated for 1-4 brain metastases (20 lesions total). For a single collimator setting, the gradient in the axial plane was steepest when prescribed to the 56-63% (4 mm), 62-70% (8 mm), and 77-84% (16 mm) IDL, respectively. Through utilization of the optimization technique, beam-on time was reduced by more than 15% in 16/20 lesions. The volume of normal brain receiving 12 Gy or above also decreased in many cases, and in only one instance increased by more than 0.5 cm3. This work demonstrates that IDL optimization using the shot within shot technique can reduce treatment times without degrading treatment plan quality.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Other 3 14%
Student > Bachelor 3 14%
Student > Master 2 10%
Lecturer 1 5%
Other 1 5%
Unknown 7 33%
Readers by discipline Count As %
Medicine and Dentistry 5 24%
Nursing and Health Professions 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Physics and Astronomy 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 2 10%
Unknown 9 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2018.
All research outputs
#6,866,317
of 23,008,860 outputs
Outputs from Radiation Oncology
#340
of 2,073 outputs
Outputs of similar age
#134,754
of 438,185 outputs
Outputs of similar age from Radiation Oncology
#2
of 33 outputs
Altmetric has tracked 23,008,860 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,073 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 438,185 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.