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Statin use and risk of depression: a Swedish national cohort study

Overview of attention for article published in BMC Psychiatry, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
1 news outlet
twitter
10 tweeters
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
57 Mendeley
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Title
Statin use and risk of depression: a Swedish national cohort study
Published in
BMC Psychiatry, December 2014
DOI 10.1186/s12888-014-0348-y
Pubmed ID
Authors

Cassie Redlich, Michael Berk, Lana J Williams, Jan Sundquist, Kristina Sundquist, Xinjun Li

Abstract

BackgroundStatin medications, used to prevent heart disease by reducing cholesterol, also reduce inflammation and protect against oxidative damage. As inflammation and oxidative stress occur in depression, there is interest in their potential to reduce depression risk. We investigated whether use of statin medications was associated with a change in the risk of developing depression in a very large Swedish national cohort (n¿=¿4,607,990).MethodsNational register data for adults ¿40yr was analyzed to obtain information about depression diagnoses and prescriptions of statin medications between 2006 and 2008. Associations were tested using logistic regression.ResultsUse of any statin was shown to reduce the odds of depression by 8% compared to individuals not using statin medications (OR¿=¿0.92, 95% CI, 0.89-0.96; p¿<¿0.001). Simvastatin had a protective effect (OR¿=¿0.93, 95% CI, 0.89-0.97; p¿=¿0.001), whereas atorvastatin was associated with increased risk of depression (OR¿=¿1.11, 95% CI, 1.01-1.22; p¿=¿0.032). There was a stepwise decrease in odds ratio with increasing age (OR¿¿¿40 years¿=¿0.95, OR¿¿¿50 years¿=¿0.91, OR¿¿¿60 years¿=¿0.85, OR¿¿¿70 years¿=¿0.81).ConclusionsThe use of any statin was associated with a reduction in risk of depression in individuals over the age of 40. Clarification of the strength of these protective effects, the clinical relevance of these effects and determination of which statins are most effective is needed.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Netherlands 1 2%
Switzerland 1 2%
Unknown 54 95%

Demographic breakdown

Readers by professional status Count As %
Other 12 21%
Researcher 9 16%
Student > Ph. D. Student 7 12%
Student > Bachelor 5 9%
Student > Master 5 9%
Other 12 21%
Unknown 7 12%
Readers by discipline Count As %
Medicine and Dentistry 26 46%
Psychology 7 12%
Social Sciences 4 7%
Nursing and Health Professions 3 5%
Agricultural and Biological Sciences 2 4%
Other 6 11%
Unknown 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2017.
All research outputs
#1,071,794
of 15,378,967 outputs
Outputs from BMC Psychiatry
#378
of 3,455 outputs
Outputs of similar age
#22,551
of 305,134 outputs
Outputs of similar age from BMC Psychiatry
#30
of 345 outputs
Altmetric has tracked 15,378,967 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,455 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 345 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.