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X Demographics
Mendeley readers
Attention Score in Context
| Title |
pH-Dependent entry of chikungunya virus fusion into mosquito cells
|
|---|---|
| Published in |
Virology Journal, December 2014
|
| DOI | 10.1186/s12985-014-0215-y |
| Pubmed ID | |
| Authors |
John T Nuckols, Alexander J McAuley, Yan-Jang S Huang, Kate M Horne, Stephen Higgs, Robert A Davey, Dana L Vanlandingham |
| Abstract |
BackgroundMillions of human infections caused by arthropod-borne pathogens are initiated by the feeding of an infected mosquito on a vertebrate. However, interactions between the viruses and the mosquito vector, which facilitates successful infection and transmission of virus to a subsequent vertebrate host, are still not fully understood.FindingHere we describe early chikungunya virus (CHIKV) infectious events in cells derived from one of the most important CHIKV vectors, Aedes albopictus. We demonstrated that CHIKV infection of mosquito cells depended on acidification of the endosome as indicated by significant inhibition following prophylactic treatment with the lysosomotropic drugs chloroquine, ammonium chloride, and monensin, which is consistent with observations in mammalian cells. While all three agents inhibited CHIKV infection in C6/36 cells, ammonium chloride was less toxic to cells than the other agents.ConclusionThe observation of similar mechanisms for inhibition of CHIKV infection in mosquito and mammalian cell lines suggests that conserved entry pathways are utilized by CHIKV for vertebrate and invertebrate cell types. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Researcher | 8 | 17% |
| Student > Master | 5 | 11% |
| Other | 4 | 9% |
| Professor | 3 | 6% |
| Other | 10 | 21% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 21% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Medicine and Dentistry | 7 | 15% |
| Immunology and Microbiology | 7 | 15% |
| Unspecified | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 8 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2014.
All research outputs
#16,724,604
of 25,387,480 outputs
Outputs from Virology Journal
#2,090
of 3,391 outputs
Outputs of similar age
#214,279
of 367,642 outputs
Outputs of similar age from Virology Journal
#39
of 49 outputs
Altmetric has tracked 25,387,480 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,391 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,642 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.