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pH-Dependent entry of chikungunya virus fusion into mosquito cells

Overview of attention for article published in Virology Journal, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 tweeters
facebook
1 Facebook page

Citations

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8 Dimensions

Readers on

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23 Mendeley
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Title
pH-Dependent entry of chikungunya virus fusion into mosquito cells
Published in
Virology Journal, December 2014
DOI 10.1186/s12985-014-0215-y
Pubmed ID
Authors

John T Nuckols, Alexander J McAuley, Yan-Jang S Huang, Kate M Horne, Stephen Higgs, Robert A Davey, Dana L Vanlandingham

Abstract

BackgroundMillions of human infections caused by arthropod-borne pathogens are initiated by the feeding of an infected mosquito on a vertebrate. However, interactions between the viruses and the mosquito vector, which facilitates successful infection and transmission of virus to a subsequent vertebrate host, are still not fully understood.FindingHere we describe early chikungunya virus (CHIKV) infectious events in cells derived from one of the most important CHIKV vectors, Aedes albopictus. We demonstrated that CHIKV infection of mosquito cells depended on acidification of the endosome as indicated by significant inhibition following prophylactic treatment with the lysosomotropic drugs chloroquine, ammonium chloride, and monensin, which is consistent with observations in mammalian cells. While all three agents inhibited CHIKV infection in C6/36 cells, ammonium chloride was less toxic to cells than the other agents.ConclusionThe observation of similar mechanisms for inhibition of CHIKV infection in mosquito and mammalian cell lines suggests that conserved entry pathways are utilized by CHIKV for vertebrate and invertebrate cell types.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 39%
Researcher 3 13%
Professor 3 13%
Other 3 13%
Student > Postgraduate 1 4%
Other 4 17%
Readers by discipline Count As %
Medicine and Dentistry 7 30%
Biochemistry, Genetics and Molecular Biology 6 26%
Agricultural and Biological Sciences 5 22%
Unspecified 2 9%
Immunology and Microbiology 2 9%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2014.
All research outputs
#2,234,058
of 5,036,026 outputs
Outputs from Virology Journal
#590
of 1,362 outputs
Outputs of similar age
#68,424
of 174,359 outputs
Outputs of similar age from Virology Journal
#31
of 50 outputs
Altmetric has tracked 5,036,026 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 1,362 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.