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Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Overview of attention for article published in Arthritis Research & Therapy, November 2017
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  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
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Mentioned by

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1 patent

Citations

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8 Dimensions

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8 Mendeley
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Title
Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis
Published in
Arthritis Research & Therapy, November 2017
DOI 10.1186/s13075-017-1455-1
Pubmed ID
Authors

Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw

Abstract

Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in primates are not available. Therefore, we investigated the presence of RF, anti-CarP antibodies and ACPA in rhesus monkeys before and after collagen-induced arthritis immunizations. In previous studies, arthritis was induced in groups of rhesus monkeys by immunisation with collagen following pre-treatment with placebo, abatacept or Roactemra. Previously collected serum was used to measure, autoantibodies by ELISA, detecting anti-CarP antibodies, RF-IgM and antibodies against CCP2, citrullinated myelin basic protein and citrullinated fibrinogen. Out of the three autoantibodies, only anti-CarP antibodies were detectable in resus monkeys with arthritis. RF-IgM and ACPA were undetectable and below the detection limit of the ELISA. The level of anti-CarP antibodies increases over time and, similar to in humans and mice, these autoantibodies were already detectable before clinical disease onset. Furthermore, preventive treatment with abatacept (CTLA4/IgG1-Fc fusion protein) inhibited the development of anti-CarP antibodies after immunization, while this was less evident for preventive Roactemra (anti-IL6-receptor) treatment. Moreover, disease progression was only reduced following abatacept treatment. Rhesus monkeys develop anti-CarP antibodies upon induction of collagen-induced arthritis, while we were unable to detect RF or ACPA. Also, the development of anti-CarP antibodies could be inhibited by preventive abatacept treatment.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Other 2 25%
Professor 1 13%
Student > Postgraduate 1 13%
Unknown 1 13%
Readers by discipline Count As %
Medicine and Dentistry 2 25%
Agricultural and Biological Sciences 2 25%
Immunology and Microbiology 1 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Unknown 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2020.
All research outputs
#4,640,373
of 14,935,583 outputs
Outputs from Arthritis Research & Therapy
#1,118
of 2,370 outputs
Outputs of similar age
#143,065
of 404,612 outputs
Outputs of similar age from Arthritis Research & Therapy
#100
of 203 outputs
Altmetric has tracked 14,935,583 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,370 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,612 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 203 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.