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Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea

Overview of attention for article published in BMC Microbiology, December 2014
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Title
Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea
Published in
BMC Microbiology, December 2014
DOI 10.1186/s12866-014-0307-2
Pubmed ID
Authors

Serej D Ley, Paul Harino, Kilagi Vanuga, Ruben Kamus, Robyn Carter, Christopher Coulter, Sushil Pandey, Julia Feldmann, Marie Ballif, Peter M Siba, Suparat Phuanukoonnon, Sebastien Gagneux, Hans-Peter Beck

Abstract

BackgroundPapua New Guinea (PNG) is a high tuberculosis (TB) burden country of the WHO Western Pacific Region, but so far research on drug resistance (DR) and genotypes of Mycobacterium tuberculosis (M. tuberculosis) was only conducted in few provinces in the country. The aim of the present study was to obtain baseline data on the level of drug resistance and the genotypic diversity of circulating M. tuberculosis in additional provinces and to investigate the differences between three selected sites across PNG.ResultsGenotyping of 147¿M. tuberculosis clinical isolates collected in Goroka, Eastern Highlands Province, in Alotau, Milne Bay Province and in Madang, Madang Province revealed three main lineages of M. tuberculosis: Lineage 4 (European-American lineage), Lineage 2 (East-Asian lineage) and Lineage 1 (Indo-Oceanic lineage). All three lineages were detected in all three sites, but the individual lineage compositions varied significantly between sites. In Madang Lineage 4 was the most prevalent lineage (76.6%), whereas in Goroka and Alotau Lineage 2 was dominating (60.5% and 84.4%, respectively) (p¿<¿0.001). Overall, phenotypic drug susceptibility testing showed 10.8% resistance to at least one of the first-line drugs tested. Of all resistant strains (23/212) 30.4% were Streptomycin mono-resistant, 17.4% were Isoniazid mono-resistant and 13% were Rifampicin mono-resistant. Multi-drug resistant (MDR) TB was found in 2.8% of all tested cases (6/212). The highest amount of MDR TB was found in Alotau in Milne Bay Province (4.6%).ConclusionA large number of drug resistant TB infections are present in the country and MDR TB has already been detected in all three surveyed regions of PNG, highlighting the importance of monitoring drug resistance and making it a high priority for the National Control Program. Due to the high prevalence of Lineage 2 in Milne Bay Province and given the frequent association of this lineage with drug resistance, monitoring of the latter should especially be scaled up in that province.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Zambia 1 1%
Unknown 79 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 14%
Student > Master 10 12%
Student > Postgraduate 8 10%
Student > Ph. D. Student 8 10%
Student > Bachelor 6 7%
Other 16 20%
Unknown 22 27%
Readers by discipline Count As %
Medicine and Dentistry 23 28%
Agricultural and Biological Sciences 10 12%
Nursing and Health Professions 6 7%
Immunology and Microbiology 6 7%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 5 6%
Unknown 28 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#18,385,510
of 22,772,779 outputs
Outputs from BMC Microbiology
#2,238
of 3,184 outputs
Outputs of similar age
#260,680
of 359,774 outputs
Outputs of similar age from BMC Microbiology
#38
of 59 outputs
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.