The Pain Self-Efficacy Questionnaire (PSEQ) is an established 10-item measure of pain self-efficacy that is widely used in clinical and research settings. However, a shorter measure would reduce patient and researcher burden and save valuable time in busy clinical settings. The aim of this study was to develop and confirm the psychometric properties of a valid and reliable two-item short form of the PSEQ (PSEQ-2). We used a large sample of 1,511 chronic pain patients which we randomly split into two smaller groups. We identified the two short-form items in sample 1 and confirmed their properties in sample 2. In order to identify the two items for the short-form measure, we selected the first item based on the highest item-total correlation. The second item was identified after a series of additional analyses. The two items identified from the PSEQ reflected confidence in ability to work and lead a normal life despite pain. The PSEQ-2's validity and internal consistency were found to be sound. Test-retest reliability, sensitivity to change and convergent validity was confirmed in a separate sample (n=140) who had recently completed an intervention designed, in part, to modify self-efficacy beliefs. The PSEQ-2 appears to be a robust measure of pain self-efficacy.