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Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis

Overview of attention for article published in BMC Musculoskeletal Disorders, December 2014
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Title
Increased proteasome activator 28 gamma (PA28γ) levels are unspecific but correlate with disease activity in rheumatoid arthritis
Published in
BMC Musculoskeletal Disorders, December 2014
DOI 10.1186/1471-2474-15-414
Pubmed ID
Authors

Melanie Gruner, Anja Moncsek, Stefan Rödiger, Dagmar Kühnhardt, Eugen Feist, Ralf Stohwasser

Abstract

PA28γ (also known as Ki, REG gamma, PMSE3), a member of the ubiquitin-and ATP-independent proteasome activator family 11S, has been proved to show proteasome-dependent and -independent effects on several proteins including tumor suppressor p53, cyclin-dependent kinase inhibitor p21 and steroid receptor co-activator 3 (SCR-3). Interestingly, PA28γ is overexpressed in pathological tissue of various cancers affecting e. g. breast, bowl and thyroids. Furthermore, anti-PA28γ autoantibodies have been linked to several autoimmune disorders. The aim of this study was to develop and evaluate a novel and sensitive PA28γ sandwich ELISA for the quantification of PA28γ serum levels in patients with cancer and autoimmune diseases for diagnostic and prognostic purposes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Researcher 3 15%
Student > Master 3 15%
Student > Bachelor 3 15%
Student > Postgraduate 2 10%
Other 4 20%
Readers by discipline Count As %
Medicine and Dentistry 10 50%
Agricultural and Biological Sciences 4 20%
Biochemistry, Genetics and Molecular Biology 2 10%
Unspecified 2 10%
Chemistry 1 5%
Other 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2014.
All research outputs
#3,552,004
of 5,036,026 outputs
Outputs from BMC Musculoskeletal Disorders
#1,388
of 1,695 outputs
Outputs of similar age
#118,512
of 175,661 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#67
of 76 outputs
Altmetric has tracked 5,036,026 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,695 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,661 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.