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Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer

Overview of attention for article published in Revista da Associação Médica Brasileira, August 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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2 tweeters
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1 Facebook page

Citations

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4 Dimensions

Readers on

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16 Mendeley
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Title
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer
Published in
Revista da Associação Médica Brasileira, August 2017
DOI 10.1590/1806-9282.63.08.704
Pubmed ID
Authors

George A. M. Lins de Albuquerque, Giuliano B. Guglielmetti, João Arthur B. A. Barbosa, José Pontes Jr., Arnaldo J. C. Fazoli, Maurício D. Cordeiro, Rafael F. Coelho, Paulo Afonso de Carvalho, Fábio P. Gallucci, Guilherme P. Padovani, Rubens Park, José Cury, Henrique Nonemacher, Miguel Srougi, William C. Nahas

Abstract

To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 44%
Researcher 2 13%
Professor 1 6%
Student > Ph. D. Student 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 3 19%
Readers by discipline Count As %
Medicine and Dentistry 4 25%
Nursing and Health Professions 3 19%
Agricultural and Biological Sciences 1 6%
Environmental Science 1 6%
Computer Science 1 6%
Other 3 19%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2017.
All research outputs
#7,161,347
of 12,698,348 outputs
Outputs from Revista da Associação Médica Brasileira
#111
of 460 outputs
Outputs of similar age
#175,912
of 387,477 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#2
of 9 outputs
Altmetric has tracked 12,698,348 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 460 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,477 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.