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Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Overview of attention for article published in Malaria Journal, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
2 blogs
twitter
4 tweeters

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
92 Mendeley
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Title
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
Published in
Malaria Journal, December 2014
DOI 10.1186/1475-2875-13-483
Pubmed ID
Authors

Nicholas J White, Elizabeth A Ashley, Judith Recht, Michael J Delves, Andrea Ruecker, Frank M Smithuis, Alice C Eziefula, Teun Bousema, Chris Drakeley, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Jetsumon Prachumsri, Cindy Chu, Chiara Andolina, Germana Bancone, Tran T Hien, Mayfong Mayxay, Walter RJ Taylor, Lorenz von Seidlein, Ric N Price, Karen I Barnes, Abdoulaye Djimdé, Feiko ter Kuile, Roly Gosling, Ingrid Chen, Mehul J Dhorda, Kasia Stepniewska, Philippe Guérin, Charles J Woodrow, Arjen M Dondorp, Nicholas PJ Day, Francois H Nosten

Abstract

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 1%
Madagascar 1 1%
United Kingdom 1 1%
Brazil 1 1%
Tanzania, United Republic of 1 1%
United States 1 1%
Burkina Faso 1 1%
Unknown 85 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 33%
Student > Ph. D. Student 19 21%
Student > Bachelor 9 10%
Student > Master 8 9%
Other 8 9%
Other 18 20%
Readers by discipline Count As %
Medicine and Dentistry 31 34%
Agricultural and Biological Sciences 27 29%
Unspecified 11 12%
Biochemistry, Genetics and Molecular Biology 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 10 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#936,955
of 12,440,396 outputs
Outputs from Malaria Journal
#223
of 3,643 outputs
Outputs of similar age
#24,459
of 281,818 outputs
Outputs of similar age from Malaria Journal
#27
of 277 outputs
Altmetric has tracked 12,440,396 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,643 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 277 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.