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Chaperones

Overview of attention for book
Cover of 'Chaperones'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Targeted Deletion of Hsf1, 2, and 4 Genes in Mice
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    Chapter 2 Role of Heat Shock Factors in Stress-Induced Transcription
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    Chapter 3 Monitoring of the Heat Shock Response with a Real-Time Luciferase Reporter
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    Chapter 4 Quantitative Profiling of Chaperone/Client Interactions with LUMIER Assay
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    Chapter 5 Measurement of Chaperone-Mediated Effects on Polyglutamine Protein Aggregation by the Filter Trap Assay
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    Chapter 6 Fluorescent-Linked Enzyme Chemoproteomic Strategy (FLECS) for Identifying HSP70 Inhibitors
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    Chapter 7 A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine
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    Chapter 8 Primary Colorectal Cells Culture as a Translational Research Model
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    Chapter 9 Cell Death and Survival Assays
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    Chapter 10 Detecting the Potential Pharmacological Synergy of Drug Combination by Viability Assays In Vitro
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    Chapter 11 Proteomic Profiling of Hsp90 Inhibitors
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    Chapter 12 Analysis of HspB1 (Hsp27) Oligomerization and Phosphorylation Patterns and Its Interaction with Specific Client Polypeptides
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    Chapter 13 Nucleotide Exchange Factors for Hsp70 Chaperones
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    Chapter 14 Determination of Hsp90 Activity Through Activation of Glucocorticoid Receptors in Yeast
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    Chapter 15 Bacterial Hsp90 ATPase Assays
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    Chapter 16 Detecting Posttranslational Modifications of Hsp90
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    Chapter 17 Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90)
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    Chapter 18 A Workflow Guide to RNA-seq Analysis of Chaperone Function and Beyond
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    Chapter 19 Computational Modeling of the Hsp90 Interactions with Cochaperones and Small-Molecule Inhibitors
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    Chapter 20 Computational Analysis of the Chaperone Interaction Networks
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    Chapter 21 Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer
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    Chapter 22 Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody
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    Chapter 23 Detection and Analysis of Extracellular Hsp90 (eHsp90)
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    Chapter 24 Molecular Chaperone Receptors
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    Chapter 25 Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy
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    Chapter 26 A Novel Heat Shock Protein 70-based Vaccine Prepared from DC-Tumor Fusion Cells
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    Chapter 27 Hsp70: A Cancer Target Inside and Outside the Cell
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    Chapter 28 Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding
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    Chapter 29 Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors
Attention for Chapter 25: Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Citations

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Chapter title
Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy
Chapter number 25
Book title
Chaperones
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7477-1_25
Pubmed ID
Book ISBNs
978-1-4939-7476-4, 978-1-4939-7477-1
Authors

Chunqing Guo, John R. Subjeck, Xiang-Yang Wang

Abstract

Large heat shock proteins (HSPs) or stress proteins, including Hsp110 and Grp170, are unique molecular chaperones with superior capability of shuttling tumor protein antigens into professional antigen-presenting cells, such as dendritic cells, for highly efficient cross-presentation and T cell priming. Reconstituted chaperone complexes of large HSP and tumor protein antigen have been demonstrated to generate a robust antigen-specific T lymphocyte response with therapeutic potency against multiple cancer types in preclinical models. Here, we describe the methods for preparing this recombinant chaperone complex vaccine and analyzing the vaccine-induced activation of antigen-specific T cells using in vitro and in vivo systems.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 33%
Student > Ph. D. Student 2 17%
Other 1 8%
Student > Doctoral Student 1 8%
Student > Master 1 8%
Other 0 0%
Unknown 3 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 17%
Agricultural and Biological Sciences 1 8%
Unspecified 1 8%
Materials Science 1 8%
Chemistry 1 8%
Other 0 0%
Unknown 6 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#12,652,452
of 16,579,327 outputs
Outputs from Methods in molecular biology
#4,267
of 9,632 outputs
Outputs of similar age
#277,578
of 416,366 outputs
Outputs of similar age from Methods in molecular biology
#738
of 1,823 outputs
Altmetric has tracked 16,579,327 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,632 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 416,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,823 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.