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Activated lymphocytes as a metabolic model for carcinogenesis

Overview of attention for article published in Cancer & Metabolism, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 208)
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

blogs
1 blog
twitter
2 X users
patent
1 patent

Citations

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76 Dimensions

Readers on

mendeley
142 Mendeley
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Title
Activated lymphocytes as a metabolic model for carcinogenesis
Published in
Cancer & Metabolism, January 2013
DOI 10.1186/2049-3002-1-5
Pubmed ID
Authors

Andrew N Macintyre, Jeffrey C Rathmell

Abstract

Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify their metabolism after activation by foreign antigens to shift from an energetically efficient oxidative metabolism to a highly glycolytic and glutamine-dependent metabolic program. This metabolic transition enables T cell growth, proliferation, and differentiation. In both activated T cells and cancer cells metabolic reprogramming is achieved by similar mechanisms and offers similar survival and cell growth advantages. Activated T cells thus present a useful model with which to study the development of tumor metabolism. Here, we review the metabolic similarities and distinctions between activated T cells and cancer cells, and discuss both the common signaling pathways and master metabolic regulators that lead to metabolic rewiring. Ultimately, understanding how and why T cells adopt a cancer cell-like metabolic profile may identify new therapeutic strategies to selectively target tumor metabolism or inflammatory immune responses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 1%
Sweden 1 <1%
Czechia 1 <1%
Russia 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 135 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 38 27%
Student > Ph. D. Student 21 15%
Student > Bachelor 15 11%
Student > Doctoral Student 12 8%
Student > Master 11 8%
Other 28 20%
Unknown 17 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 32%
Biochemistry, Genetics and Molecular Biology 27 19%
Immunology and Microbiology 19 13%
Medicine and Dentistry 14 10%
Chemistry 3 2%
Other 7 5%
Unknown 27 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2022.
All research outputs
#2,691,949
of 23,230,825 outputs
Outputs from Cancer & Metabolism
#32
of 208 outputs
Outputs of similar age
#28,605
of 282,811 outputs
Outputs of similar age from Cancer & Metabolism
#5
of 6 outputs
Altmetric has tracked 23,230,825 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 208 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,811 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.