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Attention Score in Context
| Title |
Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2
|
|---|---|
| Published in |
Journal of Translational Medicine, December 2014
|
| DOI | 10.1186/s12967-014-0337-4 |
| Pubmed ID | |
| Authors |
Nina A Dzhoyashvili, Anastasia Yu Efimenko, Tatiana N Kochegura, Natalia I Kalinina, Natalia V Koptelova, Olga Yu Sukhareva, Marina V Shestakova, Renat S Akchurin, Vsevolod A Tkachuk, Yelena V Parfyonova |
| Abstract |
BackgroundMultipotent mesenchymal stem/stromal cells (MSC) including adipose-derived stromal cells (ADSC) have been successfully applied for cardiovascular diseases treatment. Their regenerative potential is considered due to the multipotency, paracrine activity and immunologic privilege. However, therapeutic efficacy of autologous MSC for myocardial ischemia therapy is modest. We analyzed if ADSC properties are attenuated in patients with chronic diseases such as coronary artery disease (CAD) and diabetes mellitus type 2 (T2DM).Methods and resultsADSC were isolated from subcutaneous fat tissue of patients without established cardiovascular diseases and metabolic disorders (control group, n¿=¿19), patients with CAD only (n¿=¿32) and patients with CAD and T2DM (n¿=¿28). ADSC phenotype (flow cytometry) was CD90+/CD73+/CD105+/CD45¿/CD31¿ and they were capable of adipogenic and osteogenic differentiation. ADSC morphology and immunophenotype were similar for all patients, but ADSC from patients with CAD and T2DM had higher proliferation activity and shorter telomeres compared to control patients.ADSC conditioned media stimulated capillary-like tubes formation by endothelial cells (EA.hy926), but this effect significantly decreased for patients with CAD (p¿=¿0.03) and with CAD¿+¿T2DM (p¿=¿0.017) compared to the control group. Surprisingly we revealed significantly higher secretion of some pro-angiogenic factors (ELISA) by ADSC: vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) for patients with CAD and HGF and placental growth factor (PlGF) for patients with CAD¿+¿T2DM. Among angiogenesis inhibitors such as thrombospondin-1, endostatin and plasminogen activator inhibitor-1 (PAI-1) level of PAI-1 in ADSC conditioned media was significantly higher for patients with CAD and CAD¿+¿T2DM compared to the control group (p¿<¿0.01). Inhibition of PAI-1 in ADSC conditioned media by neutralizing antibodies partially restored ADSC angiogenic activity (p¿=¿0.017).ConclusionsADSC angiogenic activity is significantly declined in patients with CAD and T2DM, which could restrict the effectiveness of autologous ADSC cell therapy in these cohorts of patients. This impairment might be due to the disturbance in coordinated network of pro- and anti-angiogenic growth factors secreted by ADSC. Changes in ADSC secretome differ between patients with CAD and T2DM and further investigation are necessary to reveal the MSC-involved mechanisms of cardiovascular and metabolic diseases and develop novel approaches to their correction using the methods of regenerative medicine. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 83 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 17% |
| Student > Bachelor | 13 | 15% |
| Student > Ph. D. Student | 10 | 12% |
| Student > Postgraduate | 10 | 12% |
| Student > Master | 10 | 12% |
| Other | 18 | 21% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 35% |
| Agricultural and Biological Sciences | 14 | 17% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Engineering | 3 | 4% |
| Immunology and Microbiology | 2 | 2% |
| Other | 9 | 11% |
| Unknown | 16 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2014.
All research outputs
#20,246,428
of 22,774,233 outputs
Outputs from Journal of Translational Medicine
#3,307
of 3,984 outputs
Outputs of similar age
#302,542
of 361,208 outputs
Outputs of similar age from Journal of Translational Medicine
#89
of 123 outputs
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