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Topical zoledronic acid decreases micromotion induced bone resorption in a sheep arthroplasty model

Overview of attention for article published in BMC Musculoskeletal Disorders, November 2017
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2 tweeters
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1 Facebook page

Citations

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2 Dimensions

Readers on

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14 Mendeley
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Title
Topical zoledronic acid decreases micromotion induced bone resorption in a sheep arthroplasty model
Published in
BMC Musculoskeletal Disorders, November 2017
DOI 10.1186/s12891-017-1802-z
Pubmed ID
Authors

Thomas Jakobsen, Søren Kold, Juan Shiguetomi-Medina, Jorgen Baas, Kjeld Soballe, Ole Rahbek

Abstract

Initial micromotion of a total hip replacement is associated with aseptic loosening. The use of bisphosphonates could be one way to reduce peri-implant bone resorption induced by micromotion. Bisphosphonates compounds are inhibitors of bone resorption. The aim of this study was to investigate whether local treatment with bisphosphonate would reduce bone resorption and fibrous tissue around an experimental implant subjected to micromotion. One micromotion implant were inserted into each medial femoral condyle in ten sheep. During each gait cycle the implant axially piston 0.5 mm. During surgery one of the femoral condyles were locally treated with 0.8 mg zoledronate. The other condyle served as control. Observation period was 12 weeks. Histological evaluation showed a fibrous capsule around both the control and bisphosphonate implants. Histomorphometrical analysis showed that 97% of the surface on both control and bisphosphonate implants were covered by fibrous tissue. However, the bisphosphonate was able to preserve bone in a 1 mm zone around the implants. This study indicates that local treatment with bisphosphonate cannot prevent the formation of a fibrous capsule around an implant subjected to micromotion, but bisphosphonate is able to reduce resorption of peri-prosthetic bone.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 14%
Student > Master 2 14%
Professor 2 14%
Student > Ph. D. Student 1 7%
Student > Bachelor 1 7%
Other 4 29%
Unknown 2 14%
Readers by discipline Count As %
Medicine and Dentistry 7 50%
Nursing and Health Professions 2 14%
Computer Science 1 7%
Unspecified 1 7%
Engineering 1 7%
Other 0 0%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2018.
All research outputs
#7,736,047
of 12,381,265 outputs
Outputs from BMC Musculoskeletal Disorders
#1,514
of 2,442 outputs
Outputs of similar age
#195,871
of 353,367 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#85
of 148 outputs
Altmetric has tracked 12,381,265 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,367 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 148 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.